3.4.24.B3: matrix metalloproteinase-11

This is an abbreviated version!
For detailed information about matrix metalloproteinase-11, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B3 matrix metalloproteinase-11

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
7	Activating Compound
6	AA Sequence
17	Application
1	CAS Registry Number
24	Cloned(Commentary)
2	Crystallization (Commentary)
1886	Disease/ Diagnostics
5	Expression
20	General Information
73	Inhibitors
53	Ki Value [mM]
12	KM Value [mM]
11	Localization
16	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
168	Organism
7	pH Optimum
9	Posttranslational Modification
21	Protein Variants
7	Purification (Commentary)
3	Reaction
14	Reaction Type
57	Reference
6	Renatured (Commentary)
91	Source Tissue
6	Specific Activity [micromol/min/mg]
86	Substrates and Products (Substrate)
12	Subunits
127	Synonyms
7	Temperature Optimum [°C]
16	Turnover Number [1/s]

Expression

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Expression on EC 3.4.24.B3 - matrix metalloproteinase-11

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide Go to Expression Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

EXPRESSION

ORGANISM

UNIPROT

LITERATURE

enzyme expression is upregulated 4323times in canine mammary tumor state compared to normal mammary gland tissue

Canis lupus familiaris

D6R1X0

734762

MMP-11 expression is upregulated in papillary thyroid carcinoma

Homo sapiens

P24347

754241

ST3 is thyroid hormone T3-inducible in Xenopus laevis. the mRNA is strongly upregulated by stage 58 in the tadpole intestine, prior to any detectable epithelial apoptosis

Xenopus laevis

-

707835

stromelysin-3 is slightly downregulated in obese adipose tissue compared to non-obese adipose tissue

Mus musculus

-

707379

treatment of BCS-TC2 cells with butyrate and trichostatin A (histone deacetylase inhibitors) increases MMP11 promoter activity 1.5-2fold and protein expression 1.4-1.7fold. Sp1 is involved in MMP11 basal expression and is essential for the upregulation of transcription by histone deacetylase inhibitors. ERK1/2-mitogen-activated protein kinase, but not p38-MAPK or JNK, is involved in the upregulation of MMP11 by histone deacetylase inhibitors

Homo sapiens

-

718998