3.4.24.B3: matrix metalloproteinase-11

This is an abbreviated version, for detailed information about matrix metalloproteinase-11, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B3 matrix metalloproteinase-11

Source Tissue

Source Tissue on EC 3.4.24.B3 - matrix metalloproteinase-11

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SOURCE TISSUE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
SOURCE
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subcutaneous and gonadal adipose tissue
Manually annotated by BRENDA team
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increased expression of MMP11 at mRNA and protein levels in cell lines and primary tumors of gastric cancer. Overexpression of MMP11 induced proliferation and invasion in AGS cells
Manually annotated by BRENDA team
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MMP11 protein is frequently detected in sera of common cancer patients including gastric cancer
Manually annotated by BRENDA team
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mouse colon cancer cells
Manually annotated by BRENDA team
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larval intestinal
Manually annotated by BRENDA team
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ST-3+/TIMP-2- (stromelysin-3+/matrix metalloproteinase TIMP-2)-phenotype is an adverse prognosticator in esophageal cancer patients
Manually annotated by BRENDA team
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BGC823. MMP11 may play an important role in the control of cell proliferation and tumor development in gastric cancer
Manually annotated by BRENDA team
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expression of stromelysin-3 (matrix metalloproteinase-11) in macrophages of murine thymus following thymocyte apoptosis
Manually annotated by BRENDA team
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upregulation of stromelysin-3 in the thymus following thymocyte apoptosis
Manually annotated by BRENDA team
additional information