3.4.24.B3: matrix metalloproteinase-11

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For detailed information about matrix metalloproteinase-11, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.24 Metalloendopeptidases

                3.4.24.B3 matrix metalloproteinase-11

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Results	in table
7	Activating Compound
6	AA Sequence
17	Application
1	CAS Registry Number
24	Cloned(Commentary)
2	Crystallization (Commentary)
1886	Disease/ Diagnostics
5	Expression
20	General Information
73	Inhibitors
53	Ki Value [mM]
12	KM Value [mM]
11	Localization
16	Metals/Ions
12	Molecular Weight [Da]
21	Natural Substrates/ Products (Substrates)
168	Organism
7	pH Optimum
9	Posttranslational Modification
21	Protein Variants
7	Purification (Commentary)
3	Reaction
14	Reaction Type
57	Reference
6	Renatured (Commentary)
91	Source Tissue
6	Specific Activity [micromol/min/mg]
86	Substrates and Products (Substrate)
12	Subunits
127	Synonyms
7	Temperature Optimum [°C]
16	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.24.B3 - matrix metalloproteinase-11

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

catalytic domain complexed with a phosphinic inhibitor mimicking the transition state, hanging drop method, 5 mg/ml protein in 0.05 M MES, pH 5.5, 0.5 M ammonium sulfate, 1% v/v trifluoroethanol, 4°C, a few months, X-ray diffraction structure determination at 2.6 A resolution and analysis

Mus musculus

Q02853

652852

enzyme complexed with a phosphinic inhibitor, inhibitor to protein ratio is 2.2:1, in presence of detergent CHAPS, hanging drop method, 5 mg/ml protein in 0.05 M MES, pH 5.5, 0.5 M ammonium sulfate, 1% v/v trifluoroethanol, X-ray diffraction structure determination at 2.6 A resolution and analysis

Mus musculus

Q02853

649230