3.4.24.B3: matrix metalloproteinase-11

This is an abbreviated version, for detailed information about matrix metalloproteinase-11, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B3 matrix metalloproteinase-11

KI Value

KI Value on EC 3.4.24.B3 - matrix metalloproteinase-11

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.000006
matrix metalloproteinase inhibitor AG3340
-
pH 7.6, 37C
0.0000009
N-alpha-(2-[[(1-[[(4,6-dichloro-1H-indol-2-yl)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-5-phenylpentanoyl)-L-tryptophanamide
-
-
0.000005
N-alpha-(2-[[(1-[[(6,8-dichloro-2-oxo-2H-chromen-3-yl)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-5-phenylpentanoyl)-L-tryptophanamide
-
-
0.000022
N-alpha-(2-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-4-methylpentanoyl)-L-tryptophanamide
-
-
0.000015
N-alpha-(2-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-4-naphthalen-2-ylbutanoyl)-L-tryptophanamide
-
-
0.000009
N-alpha-(2-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-4-phenylbutanoyl)-L-tryptophanamide
-
-
0.000005
N-alpha-(2-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-5-phenylpentanoyl)-L-tryptophanamide
-
-
0.000033
N-alpha-(2-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-6-phenylhexanoyl)-L-tryptophanamide
-
-
0.000034
N-alpha-(2-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]tetradecanoyl)-L-tryptophanamide
-
-
0.000051
N-alpha-(2-[[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]methyl]-4-phenylbutanoyl)-L-tryptophanamide
-
-
0.0001
N-alpha-(2-[[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]methyl]-5-phenylpentanoyl)-L-tryptophanamide
-
-
0.000005
N-alpha-(2-[[(1-[[3-(benzyloxy)propanoyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-5-phenylpentanoyl)-L-tryptophanamide
-
-
0.000004
N-alpha-(2-[[(1-[[N-(3-chlorophenyl)-b-alanyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-5-phenylpentanoyl)-L-tryptophanamide
-
-
0.00001
N-alpha-(2-[[(1-[[N-(5-chloro-2-hydroxyphenyl)-b-alanyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-5-phenylpentanoyl)-L-tryptophanamide
-
-
0.000002
N-alpha-(3-[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]-2-[[(4-methoxybenzyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.00026
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[(cyclohexylsulfanyl)methyl]propanoyl)-L-tryptophanamide
-
-
0.00005
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[(decylsulfanyl)methyl]propanoyl)-L-tryptophanamide
-
-
0.000026
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[(naphthalen-2-ylsulfanyl)methyl]propanoyl)-L-tryptophanamide
-
-
0.00053
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2-ethoxy-2-oxoethyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.0003
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2-methoxy-2-oxoethyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.000165
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2-methylpropyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.00008
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2-phenylethyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.000275
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(3-ethoxy-3-oxopropyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.00038
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(3-methoxy-3-oxopropyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.000066
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(3-methoxyphenyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.000165
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(3-methylbutyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.000017
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(4-chlorobenzyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.000002
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(4-methoxybenzyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.000033
N-alpha-(3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(furan-2-ylmethyl)sulfanyl]methyl]propanoyl)-L-tryptophanamide
-
-
0.0003
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-([[2-(1-methylethyl)phenyl]sulfanyl]methyl)propanoyl]-L-tryptophanamide
-
-
0.000413
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-([[2-(trifluoromethoxy)phenyl]sulfanyl]methyl)propanoyl]-L-tryptophanamide
-
-
0.000615
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-([[3-(trifluoromethoxy)biphenyl-4-yl]sulfanyl]methyl)propanoyl]-L-tryptophanamide
-
-
0.00033
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-([[4-bromo-2-(trifluoromethoxy)phenyl]sulfanyl]methyl)propanoyl]-L-tryptophanamide
-
-
0.00001
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[(phenylsulfanyl)methyl]propanoyl]-L-tryptophanamide
-
-
0.000077
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2,4-di-tert-butylphenyl)sulfanyl]methyl]propanoyl]-L-tryptophanamide
-
-
0.00043
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2,5-dimethoxyphenyl)sulfanyl]methyl]propanoyl]-L-tryptophanamide
-
-
0.000113
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2-bromophenyl)sulfanyl]methyl]propanoyl]-L-tryptophanamide
-
-
0.00027
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2-ethylphenyl)sulfanyl]methyl]propanoyl]-L-tryptophanamide
-
-
0.00023
N-alpha-[(2R)-3-[[(1S)-1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl](hydroxy)phosphoryl]-2-[[(2-methoxyphenyl)sulfanyl]methyl]propanoyl]-L-tryptophanamide
-
-
0.00002
N-alpha-[2-([[1-(acetylamino)-2-phenylethyl](hydroxy)phosphoryl]methyl)-5-phenylpentanoyl]-L-tryptophanamide
-
-
0.000008
N-alpha-[2-([[1-([N-[(benzyloxy)carbonyl]-D-alanyl]amino)-2-phenylethyl](hydroxy)phosphoryl]methyl)-5-phenylpentanoyl]-L-tryptophanamide
-
-
0.000006
N-alpha-[2-([[1-([N-[(benzyloxy)carbonyl]-D-leucyl]amino)-2-phenylethyl](hydroxy)phosphoryl]methyl)-5-phenylpentanoyl]-L-tryptophanamide
-
-
0.000005
N-alpha-[2-([[1-[[(benzyloxy)carbonyl]amino]-2-(3-bromophenyl)ethyl](hydroxy)phosphoryl]methyl)-5-phenylpentanoyl]-L-tryptophanamide
-
-
0.00035
N-alpha-[2-benzyl-3-[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]propanoyl]-L-tryptophanamide
-
-
0.0000015
N-alpha-[2-[(hydroxy[1-[(1H-indol-2-ylcarbonyl)amino]-2-phenylethyl]phosphoryl)methyl]-5-phenylpentanoyl]-L-tryptophanamide
-
-
0.000015
N-alpha-[2-[(hydroxy[2-phenyl-1-[(N-phenyl-b-alanyl)amino]ethyl]phosphoryl)methyl]-5-phenylpentanoyl]-L-tryptophanamide
-
-
0.0000042
N-alpha-[2-[(hydroxy[2-phenyl-1-[(quinolin-2-ylcarbonyl)amino]ethyl]phosphoryl)methyl]-5-phenylpentanoyl]-L-tryptophanamide
-
-
0.000016
N-alpha-[3-(benzyloxy)-2-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]propanoyl]-L-tryptophanamide
-
-
0.000175
N-alpha-[3-(benzyloxy)-2-[[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]methyl]propanoyl]-L-tryptophanamide
-
-
0.000074
N-alpha-[3-[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]-2-(naphthalen-2-ylmethyl)propanoyl]-L-tryptophanamide
-
-
0.0027
N-alpha-[3-[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]-2-methylpropanoyl]-L-tryptophanamide
-
-
0.000036
N-alpha-[3-[(1-[[(benzyloxy)carbonyl]amino]ethyl)(hydroxy)phosphoryl]-2-[(benzylsulfanyl)methyl]propanoyl]-L-tryptophanamide
-
-
0.000027
N2-(2-[[(1-[[(benzyloxy)carbonyl]amino]-2-phenylethyl)(hydroxy)phosphoryl]methyl]-5-phenylpentanoyl)-3-[(3,5-dinitrophenyl)amino]-L-alaninamide
-
-