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3.4.24.B3: matrix metalloproteinase-11

This is an abbreviated version!
For detailed information about matrix metalloproteinase-11, go to the full flat file.

Word Map on EC 3.4.24.B3

Reaction

proteolytic degradation of proteins =

Synonyms

M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B3 matrix metalloproteinase-11

Substrates Products

Substrates Products on EC 3.4.24.B3 - matrix metalloproteinase-11

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Ala-S-[(4-methoxyphenyl)methyl]Cys-Trp-Ala-Arg-N3-(2,4-dinitrophenyl)-L-2,3-diamino propionylamide + H2O
(7-methoxycoumarin-4-yl)acetyl-Pro-Leu-Ala + S-[(4-methoxyphenyl)methyl]Cys-Trp-Ala-Arg-N3-(2,4-dinitrophenyl)-L-2,3-diamino propionylamide
show the reaction diagram
-
-
-
?
a1-PI + H2O
?
show the reaction diagram
-
-
-
?
aggrecan + H2O
?
show the reaction diagram
-
28 kDa N-terminal domain, cartilage proteoglycan encapsulated in polyacrylamide beads
-
?
alpha1-antitrypsin inhibitor + H2O
?
show the reaction diagram
-
-
-
?
alpha1-protease inhibitor + H2O
?
show the reaction diagram
carboxymethylated transferrin + H2O
?
show the reaction diagram
-
28 kDa N-terminal domain
-
?
casein + H2O
?
show the reaction diagram
collagen type IV + H2O
?
show the reaction diagram
collagen VI + H2O
?
show the reaction diagram
dansyl-Ala-Ala-Ala-S-(phenylmethyl)cysteine-Trp-Ala-Arg-NH2 + H2O
dansyl-Ala-Ala-Ala + S-(phenylmethyl)cysteine-Trp-Ala-Arg-NH2
show the reaction diagram
-
-
-
?
dansyl-Pro-Leu-Ala-(2S)-2-aminoheptanoyl-Trp-Ala-Arg-NH2 + H2O
dansyl-Pro-Leu-Ala + (2S)-2-aminoheptanoyl-Trp-Ala-Arg-NH2
show the reaction diagram
-
-
-
?
dansyl-Pro-Leu-Ala-(2S)-2-aminooctanoyl-Trp-Ala-Arg-NH2 + H2O
dansyl-Pro-Leu-Ala + (2S)-2-aminooctanoyl-Trp-Ala-Arg-NH2
show the reaction diagram
-
-
-
?
dansyl-Pro-Leu-Ala-(5-phenyl)Nva-Trp-Ala-Arg-NH2 + H2O
dansyl-Pro-Leu-Ala + (5-phenyl)Nva-Trp-Ala-Arg-NH2
show the reaction diagram
-
-
-
?
dansyl-Pro-Leu-Ala-Leu-Trp-Ala-Arg-NH2 + H2O
?
show the reaction diagram
dansyl-Pro-Leu-Ala-Met-Trp-Ala-Arg-NH2 + H2O
?
show the reaction diagram
dansyl-Pro-Leu-Ala-Nle-Trp-Ala-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
?
dansyl-Pro-Leu-Ala-Phe-Trp-Ala-Arg-NH2 + H2O
?
show the reaction diagram
-
-
-
?
dansyl-Pro-Leu-Ala-S-(phenylmethyl)Cys-Trp-Ala-Arg-NH2 + H2O
dansyl-Pro-Leu-Ala + S-(phenylmethyl)Cys-Trp-Ala-Arg-NH2
show the reaction diagram
-
-
-
?
dansyl-Pro-Leu-Ala-S-p-methoxybenzylcysteine-Trp-Ala-Arg-NH2 + H2O
?
show the reaction diagram
-
wild-type and mutants Q215R and Q215L, mutant Q215Y shows no activity with this substrate
-
?
dansyl-Pro-Leu-Ala-S-[(4-methoxyphenyl)methyl]Cys-Trp-Ala-Arg-NH2 + H2O
dansyl-Pro-Leu-Ala + S-[(4-methoxyphenyl)methyl]Cys-Trp-Ala-Arg-NH2
show the reaction diagram
dansyl-Pro-Leu-Ala-S-[(4-methoxyphenyl)methyl]Ser-Trp-Ala-Arg-NH2 + H2O
dansyl-Pro-Leu-Ala + S-[(4-methoxyphenyl)methyl]Ser-Trp-Ala-Arg-NH2
show the reaction diagram
-
-
-
?
dansyl-Pro-Leu-Phe-S-(phenylmethyl)Cys-Trp-Ala-Arg-NH2 + H2O
dansyl-Pro-Leu-Phe + S-(phenylmethyl)Cys-Trp-Ala-Arg-NH2
show the reaction diagram
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
-
28 kDa N-terminal domain
-
?
GAAGAMFLEA + H2O
GAAGA + MFLEA
show the reaction diagram
-
-
-
?
Gelatin + H2O
?
show the reaction diagram
GGAANLVRGG + H2O
GGAAN + LVRGG
show the reaction diagram
-
-
-
?
GGPLALWARGG + H2O
GGPLA + LWARGG
show the reaction diagram
-
-
-
?
GGPLGLYAGG + H2O
GGPLG + LYAGG
show the reaction diagram
-
-
-
?
GGQPRGVWGG + H2O
GGQPRG + VWGG
show the reaction diagram
-
-
-
?
GGTDAWLSGG + H2O
GGTDA + WLSGG
show the reaction diagram
-
-
-
?
GGYAELRMGG + H2O
GGYAE + LRMGG
show the reaction diagram
-
best substrate
-
?
Human alpha1-proteinase inhibitor + H2O
?
show the reaction diagram
-
preferred cleavage site: (A)/(G/A)(A)(M)(F/A)(L) (P3-P3') inability of Xenopus alpha1-proteinase inhibitor to be cleaved
-
-
?
insulin-like growth factor-binding protein-1 + H2O
2 peptides of 16 and 9 kDa MW
show the reaction diagram
-
specific for, cleavage site is the His140-Val141 bond
-
?
Laminin + H2O
?
show the reaction diagram
laminin receptor precursor + H2O
?
show the reaction diagram
protein + H2O
peptides
show the reaction diagram
additional information
?
-