3.4.24.B3: matrix metalloproteinase-11

This is an abbreviated version, for detailed information about matrix metalloproteinase-11, go to the full flat file.

Reaction

proteolytic degradation of proteins =

Synonyms

M10.007, matrix metalloproteinase 11, matrix metalloproteinase-11, matrix metalloproteinase-11/stromelysin-3, matrixin, matrixin 11, MMP stromelysin-3, MMP-11, MMP-11 proteinase, MMP11, More, MP-11, SL-3, ST-3, ST3, stromelysin 3, stromelysin-3

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.B3 matrix metalloproteinase-11

Cloned

Cloned on EC 3.4.24.B3 - matrix metalloproteinase-11

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Cloned/COMMENTARY
ORGANISM
UNIPROT
LITERATURE
expressed in COS-7 and MDA-MB-330 cells
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expressed in Escherichia coli TOP 10 cells
expressed in MCF-7 cells and MDA-MB-231 cells
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expression in Escherichia coli BL21(DE3)
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expression in MCF-7 breat adenocarcinoma cells, secretion of the enzyme
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expression of an inactive enzyme in Escherichia coli BL21(DE3), expression of a functional enzyme in NSO mouse myeloma cell line
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expression of catalytic domain connected to the hemopexin-like domain in Escherichia coli BL21(DE3)
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expression of catalytic site comprising residues 98-272 and of mutants A235P and E216A in Escherichia coli
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expression of enzyme residues Phe102-Ser276 in Escherichia coli BL21(DE3)
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expression of truncated mutant lacking the N-terminal prodomain in Escherichia coli BL21(DE3), and the C-terminal part of the hemopexin-like domain, expression of wild-type enzyme in MFC7 cells
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expression of truncated mutant lacking the N-terminal prodomain, the C-terminal part of the hemopexin-like domain, and mutant A235P in Escherichia coli BL21(DE3)
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from NIH-3T3 cells, establishing of a chemically induced, MMP11-overexpressing colon cancer model, overview
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MMP-11 expression analysis
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MMP-11 expression in healthy and cancer tissues, overview
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MMP11, expression analysis
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MP-11 expression analysis
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overexpression of the catalytic domain in Escherichia coli BL21(DE3)
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overexpression of wild-type and mutant E220A in Escherichia coli, expression of wild-type and inactive enzyme in MCF7 carcinoma cells
the enzyme lacking the signal and propeptide is expressed in Escherichia coli
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