3.4.24.42: atrolysin C

This is an abbreviated version, for detailed information about atrolysin C, go to the full flat file.

Reaction

Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 =

Synonyms

aggrecanase, atrolysin, Crotalus atrox metalloendopeptidase c, hemorrhagic metalloproteinase HT-d, Hemorrhagic toxin c and d, PI metalloproteinase, Ruberlysin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.42 atrolysin C

Reference

Reference on EC 3.4.24.42 - atrolysin C

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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Fox, J.W.; Bjarnason, J.B.
Atrolysins: metalloproteinases from Crotalus atrox venom
Methods Enzymol.
248
368-387
1995
Crotalus atrox
Manually annotated by BRENDA team
Bjarnason, J.B.; Hamilton, D.; Fox, J.W.
Studies on the mechanism of hemorrhage production by five proteolytic hemorrhagic toxins from Crotalus atrox venom
Biol. Chem. Hoppe-Seyler
369
121-129
1988
Crotalus atrox
Manually annotated by BRENDA team
Bjarnason, J.B.; Tu, A.T.
Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e
Biochemistry
17
3395-3404
1978
Crotalus atrox
Manually annotated by BRENDA team
Fox, J.W.; Campbell, R.; Beggerly, L.; Bjarnason, J.B.
Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom
Eur. J. Biochem.
156
65-72
1986
Crotalus atrox
Manually annotated by BRENDA team
Bjarnason, J.B.; Fox, J.W.
Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom
Biochim. Biophys. Acta
911
356-363
1987
Crotalus atrox
Manually annotated by BRENDA team
Shannon, J.D.; Baramova, E.N.; Bjarnason, J.B.; Fox, J.W.
Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin
J. Biol. Chem.
264
11575-11583
1989
Crotalus atrox
Manually annotated by BRENDA team
Zhang, D.; Botos, I.; Gomis-Ruth, F.X.; Doll, R.; Blood, C.; Njoroge, F.G.; Fox, J.W.; Bode, W.; Meyer, E.F.
Structural interaction of natural and synthetic inhibitors with the venom metalloproteinase, atrolysin C (form d)
Proc. Natl. Acad. Sci. USA
91
8447-8451
1994
Crotalus atrox
Manually annotated by BRENDA team
Takeya, H.; Onikura, A.; Nikai, T.; Sugihara, H.; Iwanaga, S.
Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber
J. Biochem.
108
711-719
1990
Crotalus ruber ruber
Manually annotated by BRENDA team
Mori, N.; Nikali, T.; Sugihara, H.; Tu, A.T.
Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom
Arch. Biochem. Biophys.
253
108-121
1987
Crotalus ruber ruber
Manually annotated by BRENDA team
Tortorella, M.D.; Pratta, M.A.; Fox, J.W.; Arner, E.C.
The interglobular domain of cartilage aggrecan is cleaved by hemorrhagic metalloproteinase HT-d (atrolysin C) at the matrix metalloproteinase and aggrecanase sites
J. Biol. Chem.
273
5846-5850
1998
Crotalus atrox
Manually annotated by BRENDA team
Pinto, A.F.; Terra, R.M.; Guimaraes, J.A.; Kashiwagi, M.; Nagase, H.; Serrano, S.M.; Fox, J.W.
Structural features of the reprolysin atrolysin C and tissue inhibitors of metalloproteinases (TIMPs) interaction
Biochem. Biophys. Res. Commun.
347
641-648
2006
Crotalus atrox
Manually annotated by BRENDA team
Fox, J.W.
Atrolysin C
Handbook Of Proteolytic Enzymes(Barrett,A. J. ,Rawlings,N. D. ,Woessner,J. F. ,Eds. )Academic Press
1
671-673
2004
Crotalus atrox
-
Manually annotated by BRENDA team
Ramos, O.H.; Selistre-de-Araujo, H.S.
Comparative analysis of the catalytic domain of hemorrhagic and non-hemorrhagic snake venom metallopeptidases using bioinformatic tools
Toxicon
44
529-538
2004
Crotalus atrox (P15167)
Manually annotated by BRENDA team
Serrano, S.M.; Wang, D.; Shannon, J.D.; Pinto, A.F.; Polanowska-Grabowska, R.K.; Fox, J.W.
Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation
FEBS J.
274
3611-3621
2007
Crotalus atrox
Manually annotated by BRENDA team
Dagda, R.K.; Gasanov, S.E.; Zhang, B.; Welch, W.; Rael, E.D.
Molecular models of the Mojave rattlesnake (Crotalus scutulatus scutulatus) venom metalloproteinases reveal a structural basis for differences in hemorrhagic activities
J. Biol. Phys.
40
193-216
2014
Crotalus atrox, Crotalus atrox (Q90392), Crotalus scutulatus scutulatus
Manually annotated by BRENDA team