3.4.24.42: atrolysin C

This is an abbreviated version, for detailed information about atrolysin C, go to the full flat file.

Reaction

Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 =

Synonyms

aggrecanase, atrolysin, Crotalus atrox metalloendopeptidase c, hemorrhagic metalloproteinase HT-d, Hemorrhagic toxin c and d, PI metalloproteinase, Ruberlysin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.42 atrolysin C

KM Value

KM Value on EC 3.4.24.42 - atrolysin C

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.71
acetyl-Ala-Ala-Leu-Gly-Ala
-
-
0.76
acetyl-Glu-Ala-Leu-Gly-Ala
-
isozyme Ht-c
0.69
Acetyl-Val-Ala-Ala-Leu-Gly-Ala
-
isozyme Ht-d
0.31 - 0.45
acetyl-Val-Ala-Leu-Gly-Gly
0.62 - 0.63
Acetyl-Val-Ala-Leu-Leu-Ala
0.5
acetyl-Val-Ala-Phe-Gly-Ala
-
isozyme Ht-c
0.21
acetyl-Val-Gly-Leu-Gly-Ala
-
isozyme Ht-c
0.14 - 0.29
Glu-Ala-Leu-Tyr-Leu
0.032 - 0.11
Leu-Val-Glu-Ala-Leu-Tyr-Leu
0.023 - 0.12
Val-Glu-Ala-Leu-Tyr-Leu