Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.24.42 extracted from

  • Fox, J.W.; Campbell, R.; Beggerly, L.; Bjarnason, J.B.
    Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom (1986), Eur. J. Biochem., 156, 65-72.
    View publication on PubMed
Search for more literature for 3.4.24.42

Inhibitors

Inhibitors Comment Organism Structure
Ala-Leu-Tyr-Leu isozyme Ht-c Crotalus atrox
Amino acid hydroxamates isozyme Ht-c Crotalus atrox
additional information acetyl-Ala-Val-Leu-Gly-Ala, acetyl-Val-Glu-Leu-Gly-Ala, acetyl-Val-Lys-Leu-Gly-Ala, acetyl-Lys-Ala-Leu-Gly-Ala, acetyl-Val-Ala-Ile-Gly-Ala, furylacryloyl-Gly-L-Leu-NH2 Crotalus atrox
phosphoramidon i.e. N-[L-rhamnopyranosyl-oxyhydroxyphosphinyl]-L-leucyl-L-tryptophan, isozyme Ht-c Crotalus atrox

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.023
-
 Val-Glu-Ala-Leu-Tyr-Leu isozyme Ht-d Crotalus atrox
0.032
-
 Leu-Val-Glu-Ala-Leu-Tyr-Leu isozyme Ht-d Crotalus atrox
0.11
-
 Leu-Val-Glu-Ala-Leu-Tyr-Leu isozyme Ht-c Crotalus atrox
0.12
-
 Val-Glu-Ala-Leu-Tyr-Leu isozyme Ht-c Crotalus atrox
0.14
-
 Glu-Ala-Leu-Tyr-Leu isozyme Ht-d Crotalus atrox
0.21
-
 acetyl-Val-Gly-Leu-Gly-Ala isozyme Ht-c Crotalus atrox
0.29
-
 Glu-Ala-Leu-Tyr-Leu isozyme Ht-c Crotalus atrox
0.31
-
 acetyl-Val-Ala-Leu-Gly-Gly isozyme c, acetyl-Val-Ala-Leu-Gly-Ala, 2-aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide Crotalus atrox
0.45
-
 acetyl-Val-Ala-Leu-Gly-Gly isozyme Ht-c Crotalus atrox
0.5
-
 acetyl-Val-Ala-Phe-Gly-Ala isozyme Ht-c Crotalus atrox
0.62
-
 Acetyl-Val-Ala-Leu-Leu-Ala acetyl-Val-Ala-Ala-Leu-Gly-Ala, isozyme Ht-c Crotalus atrox
0.63
-
 Acetyl-Val-Ala-Leu-Leu-Ala isozyme Ht-d Crotalus atrox
0.69
-
 Acetyl-Val-Ala-Ala-Leu-Gly-Ala isozyme Ht-d Crotalus atrox
0.71
-
 acetyl-Ala-Ala-Leu-Gly-Ala
-
 Crotalus atrox
0.76
-
 acetyl-Glu-Ala-Leu-Gly-Ala isozyme Ht-c Crotalus atrox

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloproteinase Crotalus atrox

Organism

Organism UniProt Comment Textmining
Crotalus atrox
-
 Western diamondback rattlesnake
-

Source Tissue

Source Tissue Comment Organism Textmining
venom
-
 Crotalus atrox
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide + H2O
-
 Crotalus atrox ?
-
 ?
acetyl-Ala-Ala-Leu-Gly-Ala + H2O
-
 Crotalus atrox ?
-
 ?
acetyl-Glu-Ala-Leu-Gly-Ala + H2O
-
 Crotalus atrox ?
-
 ?
Acetyl-Val-Ala-Ala-Leu-Gly-Ala + H2O
-
 Crotalus atrox ?
-
 ?
acetyl-Val-Ala-Leu-Gly-Gly + H2O
-
 Crotalus atrox ?
-
 ?
Acetyl-Val-Ala-Leu-Leu-Ala + H2O best substrate of synthetic acetylated pentapeptides Crotalus atrox ?
-
 ?
acetyl-Val-Ala-Phe-Gly-Ala + H2O
-
 Crotalus atrox ?
-
 ?
acetyl-Val-Gly-Leu-Gly-Ala + H2O
-
 Crotalus atrox ?
-
 ?
Glu-Ala-Leu-Tyr-Leu + H2O peptide derived from insulin B-chain Crotalus atrox ?
-
 ?
Leu-Val-Glu-Ala-Leu-Tyr-Leu + H2O peptide derived from insulin B-chain, best substrate Crotalus atrox Leu-Val-Glu-Ala + Leu-Tyr-Leu
-
 ?
additional information no hydrolysis of peptide Ala-Leu-Tyr-Leu Crotalus atrox ?
-
 ?
additional information cleavage specificity, compared to hemorrhagic toxins a and b Crotalus atrox ?
-
 ?
additional information substrate requirements: small aliphatic residues at P1 (Ala or Gly) and Leu at P2 Crotalus atrox ?
-
 ?
Oxidized insulin B-chain + H2O cleavage at Gly23-Phe24 Crotalus atrox ?
-
 ?
Oxidized insulin B-chain + H2O cleavage at His5-Leu6, His10-Leu11, Ala14-Leu15 (most rapidly cleaved bond) Crotalus atrox ?
-
 ?
Oxidized insulin B-chain + H2O cleavage at Tyr16-Leu17 (slightly less rapidly cleaved bond) Crotalus atrox ?
-
 ?
Val-Glu-Ala-Leu-Tyr-Leu + H2O peptide derived from insulin B-chain Crotalus atrox ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Crotalus atrox