3.4.24.42: atrolysin C

This is an abbreviated version, for detailed information about atrolysin C, go to the full flat file.

Reaction

Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 =

Synonyms

aggrecanase, atrolysin, Crotalus atrox metalloendopeptidase c, hemorrhagic metalloproteinase HT-d, Hemorrhagic toxin c and d, PI metalloproteinase, Ruberlysin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.42 atrolysin C

Inhibitors

Inhibitors on EC 3.4.24.42 - atrolysin C

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INHIBITORS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
1,10-phenanthroline
Ala-Leu-Tyr-Leu
-
isozyme Ht-c
alpha2-Macroglobulin
-
Amino acid hydroxamates
amino acid hydroxymate
-
-
Benzyloxycarbonyl-Leu-Gly-NHOH
-
-
catrocollastatin C
-
-
-
chloromethyl ester
-
-
Collagenase inhibitor SC 44463
-
-
cysteine
-
-
Inhibitor SCH 47890
-
mechanism
phosphoramidon
Pyro-Glu-Asn-Trp
-
-
thiorphan
-
-
tissue inhibitor of metalloproteinase 3
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N-terminal domain of the tissue inhibitor of metalloproteinase 3 is a potent inhibitor
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additional information
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