Cloned (Comment) | Organism |
---|---|
- |
Crotalus atrox |
Crystallization (Comment) | Organism |
---|---|
- |
Crotalus atrox |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Crotalus atrox | |
alpha2-Macroglobulin | - |
Crotalus atrox | |
Amino acid hydroxamates | - |
Crotalus atrox | |
Benzyloxycarbonyl-Leu-Gly-NHOH | - |
Crotalus atrox | |
EDTA | - |
Crotalus atrox |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | zinc metalloproteinase | Crotalus atrox | |
Zn2+ | 1 mol zinc/mol enzyme | Crotalus atrox |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
additional information | - |
they differ by a single amino acid substitution at position 181, Ala (Cc) or Asp (Cd) | Crotalus atrox |
24000 | - |
1 * 24000, Crotalus atrox | Crotalus atrox |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Basement membranes surrounding capillaries + H2O | Crotalus atrox | together with atrolysins B and E member of the class P-I hemorrhagic toxins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crotalus atrox | - |
Western diamondback rattlesnake | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | no glycoprotein | Crotalus atrox |
Purification (Comment) | Organism |
---|---|
formerly Ht-c and Ht-d | Crotalus atrox |
from lyophilized crude venom | Crotalus atrox |
two isozymes Cc and Cd | Crotalus atrox |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Crotalus atrox | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-Aminobenzoyl-Ala-Gly-Leu-Ala 4-nitrobenzyl amide + H2O | - |
Crotalus atrox | ? | - |
? | |
Basement membrane preparation + H2O | - |
Crotalus atrox | Soluble peptides | - |
? | |
Basement membranes surrounding capillaries + H2O | together with atrolysins B and E member of the class P-I hemorrhagic toxins | Crotalus atrox | ? | - |
? | |
Collagen type IV + H2O | basement membrane component, alpha1 (MW 185000) and alpha2 (MW 170000) chain | Crotalus atrox | Hydrolyzed collagen type IV | - |
? | |
Fibrinogen + H2O | - |
Crotalus atrox | Hydrolyzed fibrinogen | - |
? | |
Fibronectin + H2O | - |
Crotalus atrox | ? | - |
? | |
Gelatin of collagen type I + H2O | i.e. denatured collagen | Crotalus atrox | Hydrolyzed gelatin of collagen type I | - |
? | |
Gelatin of collagen type III + H2O | i.e. denatured collagen | Crotalus atrox | ? | - |
? | |
Human alpha2-macroglobulin + H2O | cleavage at Arg696-Leu697 | Crotalus atrox | ? | - |
? | |
Laminin + H2O | - |
Crotalus atrox | ? | - |
? | |
Leu-Val-Glu-Ala-Leu-Tyr-Leu + H2O | cleavage at Ala-Leu | Crotalus atrox | Leu-Val-Glu-Ala + Leu-Tyr-Leu | - |
? | |
additional information | no hydrolysis of fibrin | Crotalus atrox | ? | - |
? | |
additional information | substrate digestion patterns differ from those of atrolysins A and E | Crotalus atrox | ? | - |
? | |
Nidogen + H2O | basement membrane component | Crotalus atrox | ? | - |
? | |
Oxidized insulin B-chain + H2O | - |
Crotalus atrox | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | SDS-PAGE | Crotalus atrox |
monomer | 1 * 24000, Crotalus atrox | Crotalus atrox |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
additional information | - |
pI: 6 (isozyme Cc), pI: 6.1 (isozyme Cd) | Crotalus atrox |