3.4.24.42: atrolysin C

This is an abbreviated version, for detailed information about atrolysin C, go to the full flat file.

Reaction

Cleavage of His5-/-Leu, His10-/-Leu, Ala14-/-Leu, Tyr16-/-Leu and Gly23-/-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1 =

Synonyms

aggrecanase, atrolysin, Crotalus atrox metalloendopeptidase c, hemorrhagic metalloproteinase HT-d, Hemorrhagic toxin c and d, PI metalloproteinase, Ruberlysin

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.24 Metalloendopeptidases
                3.4.24.42 atrolysin C

pH Range

pH Range on EC 3.4.24.42 - atrolysin C

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
7.3 - 10
-
about half-maximal activity at pH 7.3 and 10, isozyme Ht-d
7.5 - 9.8
-
about half-maximal activity at pH 7.5 and 9.8, isozyme Ht-c