3.4.23.B6: Mason-Pfizer monkey virus proteinase
This is an abbreviated version!
For detailed information about Mason-Pfizer monkey virus proteinase, go to the full flat file.
Word Map on EC 3.4.23.B6
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3.4.23.B6
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retroviral
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polyproteins
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capsid
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virion
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retropepsins
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flap
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g-patch
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d-type
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retroviruses
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glycine-rich
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gag-related
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pepsin-like
- 3.4.23.B6
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retroviral
- polyproteins
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capsid
- virion
- retropepsins
- flap
-
g-patch
-
d-type
- retroviruses
-
glycine-rich
-
gag-related
-
pepsin-like
Reaction
The enzyme cleaves 17 amino acids of the C-terminal 38-amino-acid cytoplasmic tail of the transmembrane protein TM of the released immature virus. =
Synonyms
M-PMV PR, M-PMV protease, Mason-Pfizer leukemia virus retropepsin, Mason-Pfizer monkey virus retropepsin, More, MPMV protease, P-MPV poteinase, P-MPV PR
ECTree
3.4.23.B6 Mason-Pfizer monkey virus proteinaseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.23.B6 - Mason-Pfizer monkey virus proteinase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
Gag polyprotein + H2O
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processing of the precursor protein into mature proteins and the functional protease
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?
Gag-Pol polyprotein + H2O
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processing of the precursor protein into mature proteins and the functional protease
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?
transmembrane glycoprotein + H2O
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cleavage site is in the cytoplasmic domain of the protein. Cleavage takes place as a postbudding event
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?
additional information
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processing of Gag polyproteins leads to reorganization of immature retroviral particles and formation of a ribonucleoprotein core. Protease catalyzed cleavage is involved in core disintegration
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?
additional information
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the individual forms of M-PMV proteinase may be responsible for cleavage at different locations in the virion or at different stages of maturation
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?
additional information
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individual forms of M-PMV proteinase may be responsible for cleavage at different parts of the budding virion, or at different stages of maturation
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?
additional information
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the enzyme is released by the autocatalytic cleavage of Gag-Pro and Gag-Pro-POl polypeptide precursors. The enzyme catalyzes the processing of viral precursors to yield the structural proteins and enzymes of the virion
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additional information
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the enzyme cleaves 17 amino acids of the C-terminal 38-amino-acid cytoplasmic tail of the transmembrane protein TM of the released immature virus, analysis of the cleavage site recognition and specificity for individual amino acids, this processing mediates the fusion with the envelope glycoprotein Env
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?
additional information
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the enzyme is involved in core disintegration cleaving the capsid protein within the major homology region, the enzyme also converts the cell-associated transmembrane protein to a virus-associated gp20
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additional information
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the enzyme is involved in incorporation of the viral glycoprotein Env during virus assembly, the enzyme also converts the cell-associated transmembrane protein TM to a virus-associated gp20, effect of mutation in the cytoplasmic domain of TM, overview
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