3.4.23.B6: Mason-Pfizer monkey virus proteinase

This is an abbreviated version!
For detailed information about Mason-Pfizer monkey virus proteinase, go to the full flat file.

Reaction

The enzyme cleaves 17 amino acids of the C-terminal 38-amino-acid cytoplasmic tail of the transmembrane protein TM of the released immature virus. =

Synonyms

M-PMV PR, M-PMV protease, Mason-Pfizer leukemia virus retropepsin, Mason-Pfizer monkey virus retropepsin, More, MPMV protease, P-MPV poteinase, P-MPV PR

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.B6 Mason-Pfizer monkey virus proteinase

Advanced search results

Do not include text mining results

Include results (more...)

Include results (more...)

Results	in table
2	Activating Compound
1	AA Sequence
1	CAS Registry Number
7	Cloned(Commentary)
2	Crystallization (Commentary)
9	Inhibitors
7	Ki Value [mM]
15	KM Value [mM]
1	Localization
3	Metals/Ions
12	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
1	Organic Solvent Stability
19	Organism
6	pH Optimum
1	pH Stability
3	pI Value
5	Posttranslational Modification
11	Protein Variants
6	Purification (Commentary)
1	Reaction
1	Reaction Type
19	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
54	Substrates and Products (Substrate)
6	Subunits
15	Synonyms
3	Temperature Optimum [°C]
13	Turnover Number [1/s]

Activating Compound

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Activating Compound on EC 3.4.23.B6 - Mason-Pfizer monkey virus proteinase

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide show all columns Go to Activating Compound Search

Please wait a moment until the data is sorted. This message will disappear when the data is sorted.

ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

NaCl

Mason-Pfizer monkey virus

-

activates at 2 M

668797

additional information

Mason-Pfizer monkey virus

-

proteolytic activity within the M-PMV Pr95Gag-Pro precursor is effectively suppressed within an assembled immature capsid, but with addition of dithiothreitol, there is a dramatic increase in protease activity. The activation of the protease results in the cleavage of p17 from the Pr95 precursor as a primary event, followed by processing of the Gag polyproteins into other mature viral proteins

646014

-