Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NaCl | activates at 2 M | Mason-Pfizer monkey virus |
Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli in inclusion bodies | Mason-Pfizer monkey virus |
Crystallization (Comment) | Organism |
---|---|
crystal structure determination of p12 mutant D26N/C7A/C106A | Mason-Pfizer monkey virus |
Protein Variants | Comment | Organism |
---|---|---|
D26N/C7A/C106A | mutant of isozyme p12 showing altered structure and low target functions | Mason-Pfizer monkey virus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
12000 | - |
2 * 12000, isozyme p12, 2 * 13000, isozyme p13, 2 * 17000, isozyme p17 | Mason-Pfizer monkey virus |
13000 | - |
2 * 12000, isozyme p12, 2 * 13000, isozyme p13, 2 * 17000, isozyme p17 | Mason-Pfizer monkey virus |
17000 | - |
2 * 12000, isozyme p12, 2 * 13000, isozyme p13, 2 * 17000, isozyme p17 | Mason-Pfizer monkey virus |
26000 | - |
x * 26000, recombinant enzyme, SDS-PAGE | Mason-Pfizer monkey virus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Gag polyprotein + H2O | Mason-Pfizer monkey virus | processing of the precursor protein into mature proteins and the functional protease | ? | - |
? | |
Gag-Pol polyprotein + H2O | Mason-Pfizer monkey virus | processing of the precursor protein into mature proteins and the functional protease | ? | - |
? | |
additional information | Mason-Pfizer monkey virus | the enzyme is involved in core disintegration cleaving the capsid protein within the major homology region, the enzyme also converts the cell-associated transmembrane protein to a virus-associated gp20 | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mason-Pfizer monkey virus | - |
P-MPV, a simian type D virus 1 retrovirus, three proteinase isozymes p17, p13, and p12 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATPQVYF(NO2)VRKA + H2O | - |
Mason-Pfizer monkey virus | ATPQVY + F(NO2)VRKA | - |
? | |
Gag polyprotein + H2O | - |
Mason-Pfizer monkey virus | ? | - |
? | |
Gag polyprotein + H2O | processing of the precursor protein into mature proteins and the functional protease | Mason-Pfizer monkey virus | ? | - |
? | |
Gag-Pol polyprotein + H2O | - |
Mason-Pfizer monkey virus | ? | - |
? | |
Gag-Pol polyprotein + H2O | processing of the precursor protein into mature proteins and the functional protease | Mason-Pfizer monkey virus | ? | - |
? | |
additional information | the enzyme is involved in core disintegration cleaving the capsid protein within the major homology region, the enzyme also converts the cell-associated transmembrane protein to a virus-associated gp20 | Mason-Pfizer monkey virus | ? | - |
? | |
additional information | cleavage site specificity, overview | Mason-Pfizer monkey virus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 26000, recombinant enzyme, SDS-PAGE | Mason-Pfizer monkey virus |
dimer | 2 * 12000, isozyme p12, 2 * 13000, isozyme p13, 2 * 17000, isozyme p17 | Mason-Pfizer monkey virus |
More | isozyme p12 structure analysis | Mason-Pfizer monkey virus |
Synonyms | Comment | Organism |
---|---|---|
Mason-Pfizer leukemia virus retropepsin | - |
Mason-Pfizer monkey virus |
Mason-Pfizer monkey virus retropepsin | - |
Mason-Pfizer monkey virus |
More | the enzyme belongs to the A2 peptidase family | Mason-Pfizer monkey virus |
P-MPV poteinase | - |
Mason-Pfizer monkey virus |
P-MPV PR | - |
Mason-Pfizer monkey virus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
4.5 | - |
- |
Mason-Pfizer monkey virus |