3.4.23.47: HIV-2 retropepsin

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For detailed information about HIV-2 retropepsin, go to the full flat file.

Reaction

Endopeptidase for which the P1 residue is preferably hydrophobic =

Synonyms

HIV-2 protease, HIV-2 proteinase, human immunodeficiency virus 2 retropepsin, More, PR, PR2, retroviral aspartic proteinase, retroviral proteinase

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.23 Aspartic endopeptidases

                3.4.23.47 HIV-2 retropepsin

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Results	in table
2	Activating Compound
15	AA Sequence
13	Application
1	CAS Registry Number
14	Cloned(Commentary)
13	Crystallization (Commentary)
5	General Information
1	General Stability
51	IC50 Value
66	Inhibitors
6	kcat/KM [mM/s]
23	Ki Value [mM]
31	KM Value [mM]
1	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
30	Organism
2	Oxidation Stability
10	PDB ID
7	pH Optimum
1	Posttranslational Modification
28	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
29	Reference
1	Renatured (Commentary)
3	Storage Stability
68	Substrates and Products (Substrate)
10	Subunits
25	Synonyms
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
34	Turnover Number [1/s]

Crystallization

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Crystallization on EC 3.4.23.47 - HIV-2 retropepsin

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CRYSTALLIZATION (Commentary)

ORGANISM

UNIPROT

LITERATURE

molecular dynamics simulations in complerx with inhibitors amprenvir and darunavir

HIV-2 subtype A

P04584

735264

analysis of 19 ligand-bound wild-type enzyme crystal structures, overview. Mutation K57L is experimentally introduced in 8 structures to help the crystallographic process

Human immunodeficiency virus 2

P04584

754210

crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398

Human immunodeficiency virus 2

-

644058, 644060, 644061, 644062, 644065, 644066

crystals grown by hanging-drop vapor diffusion method, thin tetragonal prisms, space group P4(1)2(1)2 or P4(3)2(1)2 with a=b=62.6 A and c=115.8 A

Human immunodeficiency virus 2

-

644065

in complex with inhibitor amprenavir, to 1.5 A resolution, and comparison with HIV-1 protease PR1M

Human immunodeficiency virus 2

-

718370

monoclinic crystals, vapor diffusion, hanging drops, P2(1) space group with a =36.76 A, b=58.44 A, c= 55.11 A and beta=91.20°

Human immunodeficiency virus 2

-

644062

Phe-Val-Phe-psi-CH2NH-Leu-Glu-Ile-amide, space group P4(1) or P4(3), unit-cell parameters a=b=55.1 A, c=138.9 A

Human immunodeficiency virus 2

-

644061

substrate binding pocket structure analysis

Human immunodeficiency virus 2

-

665102