3.4.23.47: HIV-2 retropepsin

This is an abbreviated version!
For detailed information about HIV-2 retropepsin, go to the full flat file.

Word Map on EC 3.4.23.47

3.4.23.47

polyproteins

antiretroviral

medicine

darunavir

saquinavir

amprenavir

lopinavir

myeloblastosis

nelfinavir

hiv-2-infected

drv

drug development

molecular biology

Reaction

Endopeptidase for which the P1 residue is preferably hydrophobic =

Synonyms

HIV-2 protease, HIV-2 proteinase, human immunodeficiency virus 2 retropepsin, More, PR, PR2, retroviral aspartic proteinase, retroviral proteinase

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.23 Aspartic endopeptidases

3.4.23.47 HIV-2 retropepsin

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Results	in table
2	Activating Compound
15	AA Sequence
13	Application
1	CAS Registry Number
14	Cloned(Commentary)
13	Crystallization (Commentary)
5	General Information
1	General Stability
51	IC50 Value
66	Inhibitors
6	kcat/KM [mM/s]
23	Ki Value [mM]
31	KM Value [mM]
1	Molecular Weight [Da]
14	Natural Substrates/ Products (Substrates)
30	Organism
2	Oxidation Stability
10	PDB ID
7	pH Optimum
1	Posttranslational Modification
28	Protein Variants
9	Purification (Commentary)
2	Reaction
1	Reaction Type
29	Reference
1	Renatured (Commentary)
3	Storage Stability
68	Substrates and Products (Substrate)
10	Subunits
25	Synonyms
4	Temperature Optimum [°C]
1	Temperature Stability [°C]
34	Turnover Number [1/s]

KM Value

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KM Value on EC 3.4.23.47 - HIV-2 retropepsin

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0.36

Ac-Tyr-Arg-Ala-Arg-Val-Phe Nph-Val-Arg-Ala-Ala-Lys

Human immunodeficiency virus 2

pH 4.7, 37°C

644063

0.06

CTLNFPISP

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.42

DKELYPLTSL

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.07

IPFAA-AQQRK

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.28

IPFAAAQQRK

Human immunodeficiency virus 2

pH 5.6, 37°C

718370

0.005

IRKILFLDG

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.08

KARLM AEALK

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.13

KARLMAEALK

Human immunodeficiency virus 2

pH 5.6, 37°C

718370

0.03

KARVL-AEAMS

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.08

L-threonyl-L-alanyl-L-threonyl-L-isoleucyl-L-methionyl-L-methionyl-L-glutaminyl-L-arginylglycyl-L-asparagine

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.025

Lys-Ala-Arg-Ile-Nle-Nph-Glu-Ala-Nle-NH2

Human immunodeficiency virus 2

pH 4.7, 37°C

644063

0.071 - 0.072

Lys-Ala-Arg-Val-Nle-(4-nitrophenylalanine)-Glu-Ala-Nle

2 entries

0.05

Lys-Ala-Arg-Val-Nle-p-nitrophenylalanine-Glu-Ala-Nle-NH2

Human immunodeficiency virus 2

679179

0.02

MSLNLPVAKV

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.74 - 0.95

NH2-ATLNFPSPW-COOH

2 entries

0.07

RGLAAPQFSL

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.3

RPQNFLQSRP

Human immunodeficiency virus 2

pH 5.6, 37°C

644059

0.099 - 0.4

VLQNYPIVQ

2 entries

0.12 - 0.203

VSQLYPIVQ

2 entries

0.172 - 0.18

VSQNYPIVQ

2 entries

0.223

VSQNYPLVQ

Human immunodeficiency virus 2

pH 5.6, 37°C

644066

0.24

VSQVYPIVQ

Human immunodeficiency virus 2

pH 5.6, 37°C

718370

0.19

VVQNYPIVQ

Human immunodeficiency virus 2

pH 5.6, 37°C

718370

0.16

YVSQNFPIVQNR

Human immunodeficiency virus 2

pH 4.7

665102

additional information

2 entries