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Literature summary for 3.4.23.47 extracted from
- Comparison of the specificity of homo- and heterodimeric linked HIV-1 and HIV-2 proteinase dimers (1998), Protein Eng., 11, 439-445.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398 | Human immunodeficiency virus 2 |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.099 | - |
VLQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 |  |
| 0.172 | - |
VSQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
| 0.203 | - |
VSQLYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
| 0.223 | - |
VSQNYPLVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GAG precursor protein of HIV-2 + H2O | Human immunodeficiency virus 2 | - |
? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Human immunodeficiency virus 2 | - |
human immunodeficiency virus type 2 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GAG precursor protein of HIV-2 + H2O | - |
Human immunodeficiency virus 2 | ? | - |
? | |
| VLQNYPIVQ + H2O | oligopeptide substrate | Human immunodeficiency virus 2 | VLQNY + PIVQ | - |
? | |
| VSQLYPIVQ + H2O | oligopeptide substrate | Human immunodeficiency virus 2 | VSQLY + PIVQ | - |
? | |
| VSQNYPIVQ + H2O | oligopeptide substrate | Human immunodeficiency virus 2 | VSQNY + PIVQ | - |
? | |
| VSQNYPLVQ + H2O | oligopeptide substrate | Human immunodeficiency virus 2 | VSQNY + PLVQ | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Human immunodeficiency virus 2 |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| retroviral aspartic proteinase | - |
Human immunodeficiency virus 2 |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0000333 | - |
VLQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
| 0.0011 | - |
VSQLYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
| 0.00213 | - |
VSQNYPIVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
| 0.00303 | - |
VSQNYPLVQ | pH 5.6, 37°C | Human immunodeficiency virus 2 | |
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