Literature summary for 3.4.23.47 extracted from

Chen, Z.; Li, Y.; Chen, E.; Hall, D.L.; Darke, P.L.; Culberson, C.; Shafer, J.A.; Kuo, L.C.
Crystal structure at 1.9-A resolution of human immunodeficiency virus (HIV) II protease complexed with L-735,524, an orally bioavailable inhibitor of the HIV proteases (1994), J. Biol. Chem., 269, 26344-26348.

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Cloned(Commentary)

Cloned (Comment)	Organism
synthetic gene for HIV-2 protease constructed and expressed in Escherichia coli	Human immunodeficiency virus 2

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystallized by hanging drop method in complex with a reduced amide inhibitor, BI-LA-398	Human immunodeficiency virus 2
monoclinic crystals, vapor diffusion, hanging drops, P2(1) space group with a =36.76 A, b=58.44 A, c= 55.11 A and beta=91.20°	Human immunodeficiency virus 2

Inhibitors

Inhibitors	Comment	Organism	Structure
indinavir	n(2(R)hydroxy-1(S)indanyl)-5-((2(S)tertiarybutylaminocarbonyl)4(3pyridylmethyl)piperazino)-4(S)-hydroxy-2(R)-phenylmethylpentanamide, piperazino, L-735,524, potent orally bioavailable inhibitor, currently in a phase II clinical trial	Human immunodeficiency virus 2

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
GAG precursor protein of HIV-2 + H2O	Human immunodeficiency virus 2	-	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Human immunodeficiency virus 2	-	human immunodeficiency virus type 2	-

Purification (Commentary)

Purification (Comment)	Organism
product of synthetic gene	Human immunodeficiency virus 2

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
GAG precursor protein of HIV-2 + H2O	-	Human immunodeficiency virus 2	?	-	?

Subunits

Subunits	Comment	Organism
dimer	2 identical subunits, homodimer	Human immunodeficiency virus 2

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Release 2023.1 (January 2023)