3.4.23.47: HIV-2 retropepsin
This is an abbreviated version!
For detailed information about HIV-2 retropepsin, go to the full flat file.
Word Map on EC 3.4.23.47
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3.4.23.47
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polyproteins
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antiretroviral
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medicine
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darunavir
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saquinavir
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amprenavir
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lopinavir
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myeloblastosis
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nelfinavir
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hiv-2-infected
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drv
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drug development
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molecular biology
- 3.4.23.47
- polyproteins
-
antiretroviral
- medicine
- darunavir
- saquinavir
- amprenavir
- lopinavir
-
myeloblastosis
- nelfinavir
-
hiv-2-infected
- drv
- drug development
- molecular biology
Reaction
Endopeptidase for which the P1 residue is preferably hydrophobic =
Synonyms
HIV-2 protease, HIV-2 proteinase, human immunodeficiency virus 2 retropepsin, More, PR, PR2, retroviral aspartic proteinase, retroviral proteinase
ECTree
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Natural Substrates Products on EC 3.4.23.47 - HIV-2 retropepsin
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REACTION DIAGRAM
additional information
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enzyme undergoes autoproteolysis at pH 3 at the G35/I36 site
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GAG precursor protein of HIV-2 + H2O
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protease is responsible for processing of the gag structural polyprotein and the release of virally encoded enzymes like protease, reverse transcriptase and integrase from the gag-pol fusion protein
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