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3.4.23.47: HIV-2 retropepsin

This is an abbreviated version!
For detailed information about HIV-2 retropepsin, go to the full flat file.

Word Map on EC 3.4.23.47

Reaction

Endopeptidase for which the P1 residue is preferably hydrophobic =

Synonyms

HIV-2 protease, HIV-2 proteinase, human immunodeficiency virus 2 retropepsin, More, PR, PR2, retroviral aspartic proteinase, retroviral proteinase

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.23 Aspartic endopeptidases
                3.4.23.47 HIV-2 retropepsin

Inhibitors

Inhibitors on EC 3.4.23.47 - HIV-2 retropepsin

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2R,4S,5S)-6-cyclohexyl-5-(3,3-dimethylbutanamido)-4-hydroxy-2-isopropyl-N-((2S,3R)-3-methyl-1-oxo-1-(phenethylamino)pentan-2-yl)hexanamide
-
synthetic inhibitor 4
(hydroxyethyl)amide isostere
-
-
2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(4,6-dimethylpyrimidin-2-ylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
hydroxyethylamine dipeptide isostere inhibitor 3
2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylmethoxy)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
hydroxyethylamine dipeptide isostere inhibitor 5
2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
hydroxyethylamine dipeptide isostere inhibitor 2
2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-4-ylsulfonyl)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
hydroxyethylamine dipeptide isostere inhibitor 4
2,6-dimethylbenzyl (2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-4-ylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylcarbamate
-
hydroxyethylamine dipeptide isostere inhibitor 1
acetyl-pepstatin
amprenavir
benzyl (S)-1-((2S,3R)-4-((R)-4-(tert-butylcarbamoyl)thiazolidin-3-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-4-amino-1,4-dioxobutan-2-ylcarbamate
-
synthetic inhibitor 1
benzyl (S)-1-((2S,3R)-4-((S) -2-(tert-butylcarbamoyl)indolin-1-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-4-amino-1,4-dioxobutan-2-ylcarbamate
-
synthetic inhibitor 2
CTLNF-PSI[CH2-NH]-PISP
-
competitive inhibition
darunavir
H-261
-
renin inhibitor
H2O2
-
inactivated after oxidation at the dimer interface, activity can be partly restored with methionine sulphoxide reductase
indinavir
lopinavir
monoclonal antibody 1696
-
-
-
N-((S)-1-((2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylmethoxy)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-3-methyl-1-oxobutan-2-yl)quinoline-2-carboxamide
-
hydroxyethylamine dipeptide isostere inhibitor 8
N-((S)-1-((2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylmethylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-3-methyl-1-oxobutan-2-yl)quinoline-2-carboxamide
-
hydroxyethylamine dipeptide isostere inhibitor 6
N-((S)-1-((2S,3R)-4-((2S,4R)-2-(tert-butylcarbamoyl)-4-(pyridin-3-ylthio)piperidin-1-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-3-methyl-1-oxobutan-2-yl)quinoline-2-carboxamide
-
hydroxyethylamine dipeptide isostere inhibitor 7
N-((S)-1-((2S,3R)-4-((3S,4aS,8aS)-3-(tert-butylcarbamoyl)-octahydroisoquinolin-2(1H)-yl)-3-hydroxy-1-phenylbutan-2-ylamino)-4-amino-1,4-dioxobutan-2-yl)quinoline-3-carboxamide
-
synthetic inhibitor 3
Phe-Val-Phe-psi-[CH2NH]-Leu-Glu-Ile-amide
-
-
saquinavir
tert-butyl (2S,3S)-5-(((2S,3R)-3-methyl-1-oxo-1-(phenethylamino)pentan-2-yl)carbamoyl)-1-cyclohexyl-3-hydroxy-6-methylheptan-2-ylcarbamate
-
synthetic inhibitor 6
tert-butyl (2S,3S,5R)-5-(((2S,3R)-3-methyl-1-oxo-1-(phenethylamino)pentan-2-yl)carbamoyl)-1-cyclohexyl-3-hydroxy-6-methylheptan-2-ylcarbamate
-
synthetic inhibitor 5
VSFNF-PSI[CH2-NH]-PQITL
-
competitive inhibition
additional information
-