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(SUMO-1)-beta-galactosidase conjugate + H2O
SUMO-1 + beta-galactosidase
SUSP1 expressed in Escherichia coli cells efficiently releases SUMO-1 from SUMO-1-beta-galactosidase fusion but not from other ubiquitin-like protein fusions, including Smt3-beta-galactosidase
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(SUMO-3)-Ran GTPase-activating protein 1 conjugate + H2O
SUMO-3 + Ran GTPase-activating protein 1
SENP6 and SENP7 prefer SUMO2 or SUMO3 in deconjugation reactions with rates comparable with those catalyzed by SENP2. In contrast to SENP2, SENP6 and SENP7 are less able to deconjugate SUMO1-RanGAP1, and products are only detected at enzyme concentrations 100 x higher than that observed for reactions containing SENP2
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acetyl-LRGG-7-amido-4-trifluoromethylcoumarin + H2O
acetyl-LRGG + 7-amino-4-trifluoromethylcoumarin
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SENP6 prefers the LRGG sequence, residues typical of Nedd8 or ubiquitin in the P3 and P4 positions
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acetyl-QTGG-7-amido-4-trifluoromethylcoumarin + H2O
acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin
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very low activity
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di-SUMO-2 + H2O
2 SUMO-2
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di-SUMO-3 + H2O
2 SUMO-3
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poly-SUMO-2 + H2O
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poly-SUMO-3 + H2O
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SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
SUMO-2 precursor + H2O
SUMO-2 + Val-Tyr
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO3 in comparison with SENP2
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SUMO-3 precursor + H2O
SUMO-3 + Val-Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO-3 in comparison with SENP2
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SUMO-modified promyelocytic leukemia protein + H2O
SUMO + promyelocytic leukemia protein
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SUMOylated TRIM28 + H2O
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i.e. tripartite motif-containing 28, also called KAP1 or TIF1beta
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additional information
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SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
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SUMO-1 precursor + H2O
SUMO-1 + His-Ser-Thr-Val
SENP6 exhibits lower rates for processing pre-SUMO-1, pre-SUMO-2, or pre-SUMO3 in comparison with SENP2
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additional information
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although SUMO-2/3 chains are the preferred substrate, SENP6 is also capable of cleaving mixed chains of SUMO-1 and SUMO-2/3
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additional information
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SENP6 reveals no detectable endopeptidase activity on the precursors of ubiquitin, Nedd8 and ISG15
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additional information
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SUSP1 expressed in Escherichia coli cells efficiently releases SUMO-1 from SUMO-1-beta-galactosidase fusion but not from other ubiquitin-like protein fusions, including Smt3zb-galactosidase, suggesting its role in the generation of matured SUMO-1 specifically from its precursors
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additional information
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SUSP1 expressed in Escherichia coli cells efficiently releases SUMO-1 from SUMO-1-beta-galactosidase fusion but not from other ubiquitin-like protein fusions, including Smt3zb-galactosidase, suggesting its role in the generation of matured SUMO-1 specifically from its precursors
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additional information
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isozyme SENP6 shows isoform specificity for SUMO2/3 over SUMO1
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