Literature summary for 3.4.22.B74 extracted from

Li, J.; Lu, D.; Dou, H.; Liu, H.; Weaver, K.; Wang, W.; Li, J.; Yeh, E.T.H.; Williams, B.O.; Zheng, L.; Yang, T.
Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway (2018), Nat. Commun., 9, 143 .

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Organism

Organism	UniProt	Comment	Textmining
Mus musculus	Q6P7W0	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
SUMOylated TRIM28 + H2O	i.e. tripartite motif-containing 28, also called KAP1 or TIF1beta	Mus musculus	?	-	?

General Information

General Information	Comment	Organism
physiological function	postnatal loss of SENP6 causes premature aging. osteochondroprogenitor-specific SENP6 knockout mice exhibit smaller skeletons, with elevated apoptosis and cell senescence in osteochondroprogenitors and chondrocytes. In Senp6-/- cells, the two most significantly elevated pathways are p53 signaling and senescence-associated secreted phenotypes, and Trp53 loss partially rescues the skeletal and cellular phenotypes caused by Senp6 loss. SENP6 interacts with, desumoylates, and stabilizes TRIM28, suppressing p53 activity	Mus musculus

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Release 2023.1 (January 2023)