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Literature summary for 3.4.22.B74 extracted from
- Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family (2008), Biochem. J., 409, 461-469.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| truncated SUMO-2 | whereas truncated SUMO-2 and -3 can substantially enhance SENP6 activity, neither truncated SUMO-1 nor truncated Nedd8 nor ubiquitin has this ability | Homo sapiens | |
| truncated SUMO-3 | whereas truncated SUMO-2 and -3 can substantially enhance SENP6 activity, neither truncated SUMO-1 nor truncated Nedd8 nor ubiquitin has this ability | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| keratinocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-LRGG-7-amido-4-trifluoromethylcoumarin + H2O | SENP6 prefers the LRGG sequence, residues typical of Nedd8 or ubiquitin in the P3 and P4 positions | Homo sapiens | acetyl-LRGG + 7-amino-4-trifluoromethylcoumarin | - |
? |  |
| acetyl-QTGG-7-amido-4-trifluoromethylcoumarin + H2O | very low activity | Homo sapiens | acetyl-QTGG + 7-amino-4-trifluoromethylcoumarin | - |
? | |
| additional information | SENP6 reveals no detectable endopeptidase activity on the precursors of ubiquitin, Nedd8 and ISG15 | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SENP6 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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