3.4.22.B74: SENP6 peptidase
This is an abbreviated version!
For detailed information about SENP6 peptidase, go to the full flat file.
Word Map on EC 3.4.22.B74
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3.4.22.B74
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leukemia
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sumo3
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sumoylation
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circadian
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promyelocytic
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ubiquitin-related
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heterodimeric
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clock
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sumo-specific
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rhythmic
- 3.4.22.B74
- leukemia
- sumo3
-
sumoylation
-
circadian
-
promyelocytic
-
ubiquitin-related
-
heterodimeric
- clock
-
sumo-specific
-
rhythmic
Reaction
The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. The enzyme catalyzes the desumoylation of SUMO-modified promyelocytic leukemia protein. SENP6 prefers the LRGG-/- sequence versus the QTGG-/- sequence. SENP6 is essential for inner kinetochore assembly. =
Synonyms
SENP6, SUSP1
ECTree
3.4.22.B74 SENP6 peptidaseAdvanced search results
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Localization on EC 3.4.22.B74 - SENP6 peptidase
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LOCALIZATION 
ORGANISM
UNIPROT
COMMENTARY 
GeneOntology No.
LITERATURE
SOURCE
SUSP1 is exclusively localized to the cytoplasm of NIH3T3 and HeLa cells
