3.4.22.B74: SENP6 peptidase

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For detailed information about SENP6 peptidase, go to the full flat file.

Reaction

The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. The enzyme catalyzes the desumoylation of SUMO-modified promyelocytic leukemia protein. SENP6 prefers the LRGG-/- sequence versus the QTGG-/- sequence. SENP6 is essential for inner kinetochore assembly. =

Synonyms

SENP6, SUSP1

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B74 SENP6 peptidase

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3	Activating Compound
2	AA Sequence
2	Cloned(Commentary)
5	Disease/ Diagnostics
7	General Information
1	Localization
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
8	Organism
3	pH Optimum
1	Purification (Commentary)
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11	Source Tissue
18	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
3	Temperature Optimum [°C]

Activating Compound

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Activating Compound on EC 3.4.22.B74 - SENP6 peptidase

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ACTIVATING COMPOUND

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

Chloroquine

Mus musculus

Q6P7W0

dose-dependently increases SENP6 protein, but not mRNA, in mouse macrophages, RAW264.7 cells. Chloroquine dose-dependently decreases the levels of microRNA-669n, which bound to 3'-UTR of SENP6 mRNA to inhibit its translation

752453

truncated SUMO-2

Homo sapiens

-

whereas truncated SUMO-2 and -3 can substantially enhance SENP6 activity, neither truncated SUMO-1 nor truncated Nedd8 nor ubiquitin has this ability

714081

-

truncated SUMO-3

Homo sapiens

-

whereas truncated SUMO-2 and -3 can substantially enhance SENP6 activity, neither truncated SUMO-1 nor truncated Nedd8 nor ubiquitin has this ability

714081

-