3.4.22.B74: SENP6 peptidase

This is an abbreviated version!
For detailed information about SENP6 peptidase, go to the full flat file.

Word Map on EC 3.4.22.B74

3.4.22.B74

leukemia

sumo3

sumoylation

circadian

promyelocytic

ubiquitin-related

heterodimeric

clock

sumo-specific

rhythmic

Reaction

The enzyme catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO-1, SUMO-2 and SUMO-3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Cleavage of Gly97-/-His98 bond in the SUMO-1 precursor with release of the propeptide His-Ser-Thr-Val. Cleavage of Gly93-/-Val94 bond in the SUMO-2 precursor with release of the propeptide Val94-Thyr. Cleavage of the Gly92-/-Val93 in the SUMO-3 precursor with release of the propeptide Pro-Glu-Ser-Ser-Leu-Ala-Gly-His-Ser-Phe. The enzyme catalyzes the desumoylation of SUMO-modified promyelocytic leukemia protein. SENP6 prefers the LRGG-/- sequence versus the QTGG-/- sequence. SENP6 is essential for inner kinetochore assembly. =

Synonyms

SENP6, SUSP1

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B74 SENP6 peptidase

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3	Activating Compound
2	AA Sequence
2	Cloned(Commentary)
5	Disease/ Diagnostics
7	General Information
1	Localization
1	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
8	Organism
3	pH Optimum
1	Purification (Commentary)
1	Reaction
8	Reference
11	Source Tissue
18	Substrates and Products (Substrate)
1	Subunits
6	Synonyms
3	Temperature Optimum [°C]

Reference

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Reference on EC 3.4.22.B74 - SENP6 peptidase

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714081

Drag, M.; Mikolajczyk, J.; Krishnakumar, I.M.; Huang, Z.; Salvesen, G.S.

Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family

Biochem. J.

409

461-469

2008

Homo sapiens

17916063

715444

Kim, K.I.; Baek, S.H.; Jeon, Y.J.; Nishimori, S.; Suzuki, T.; Uchida, S.; Shimbara, N.; Saitoh, H.; Tanaka, K.; Chung, C.H.

A new SUMO-1-specific protease, SUSP1, that is highly expressed in reproductive organs

J. Biol. Chem.

275

14102-14106

2000

Homo sapiens (Q9GZR1), Homo sapiens

10799485

715494

Lima, C.D.; Reverter, D.

Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7

J. Biol. Chem.

283

32045-32055

2008

Homo sapiens (Q9GZR1)

18799455

715706

Mukhopadhyay, D.; Arnaoutov, A.; Dasso, M.

The SUMO protease SENP6 is essential for inner kinetochore assembly

J. Cell Biol.

188

681-692

2010

Homo sapiens

20212317

716169

Hattersley, N.; Shen, L.; Jaffray, E.G.; Hay, R.T.

The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

Mol. Biol. Cell

78-90

2010

Homo sapiens (Q9GZR1)

21148299

732884

Alegre, K.O.; Reverter, D.

Structural insights into the SENP6 loop1 structure in complex with SUMO2

Protein Sci.

433-441

2014

Homo sapiens

24424631

752453

Long, Y.; Liu, X.; Wang, N.; Zhou, H.; Zheng, J.

Chloroquine attenuates LPS-mediated macrophage activation through miR-669n-regulated SENP6 protein translation

Am. J. Transl. Res.

2335-2345

2015

Mus musculus (Q6P7W0)

26807181

754848

Li, J.; Lu, D.; Dou, H.; Liu, H.; Weaver, K.; Wang, W.; Li, J.; Yeh, E.T.H.; Williams, B.O.; Zheng, L.; Yang, T.

Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway

Nat. Commun.

143

2018

Mus musculus (Q6P7W0)

29321472