3.4.22.B62: cathepsin L3

This is an abbreviated version!
For detailed information about cathepsin L3, go to the full flat file.

Word Map on EC 3.4.22.B62

3.4.22.B62

cathepsins

fasciola

hepatica

worm

schistosoma

fluke

peptidases

schistosomiasis

mansoni

adjuvant-free

japonicum

samarium

fasciolosis

collagenolytic

drug development

Reaction

70fold preference for tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin over typical cathepsin substrates with hydrophobic or aliphatic residues in the S2 position. Efficiently cleaves type I collagen over different pH and temperature conditions =

Synonyms

cathepsin L clade 3, cathepsin L3, CL3, CL3-1, CL3-2, FhCL3, FheCL3, NEJ protein 8, newly excysted juvenile protein 8, SmCL3

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B62 cathepsin L3

Advanced search results

Do not include text mining results

Include

results (more...)

Include

results (more...)

Results	in table
8	AA Sequence
1	Application
8	Cloned(Commentary)
1	Expression
6	General Information
34	Inhibitors
17	kcat/KM [mM/s]
2	Ki Value [mM]
20	KM Value [mM]
5	Localization
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
17	Organism
3	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
2	Protein Variants
5	Purification (Commentary)
1	Reaction
15	Reference
11	Source Tissue
39	Substrates and Products (Substrate)
5	Subunits
26	Synonyms
1	Temperature Optimum [°C]
20	Turnover Number [1/s]

Natural Substrates Products

print visible entries

print all entries

Go back to the abbreviated version
of the Enzyme Summary Page.

Natural Substrates Products on EC 3.4.22.B62 - cathepsin L3

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.

top print hide

Go to Natural Substrate Search

Collagen + H2O

3 entries

human immumglobulin G + H2O

Fasciola hepatica

B9VXS1, B9VXS2

partial cleavage

732474

pro-interleukin-1beta + H2O

interleukin-1beta + interleukin-1beta propeptide

Fasciola hepatica

B3TM67

753661

Type I collagen + H2O

2 entries

additional information

2 entries