3.4.22.B62: cathepsin L3

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For detailed information about cathepsin L3, go to the full flat file.

Reaction

70fold preference for tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin over typical cathepsin substrates with hydrophobic or aliphatic residues in the S2 position. Efficiently cleaves type I collagen over different pH and temperature conditions =

Synonyms

cathepsin L clade 3, cathepsin L3, CL3, CL3-1, CL3-2, FhCL3, FheCL3, NEJ protein 8, newly excysted juvenile protein 8, SmCL3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B62 cathepsin L3

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Results	in table
8	AA Sequence
1	Application
8	Cloned(Commentary)
1	Expression
6	General Information
34	Inhibitors
17	kcat/KM [mM/s]
2	Ki Value [mM]
20	KM Value [mM]
5	Localization
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
17	Organism
3	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
2	Protein Variants
5	Purification (Commentary)
1	Reaction
15	Reference
11	Source Tissue
39	Substrates and Products (Substrate)
5	Subunits
26	Synonyms
1	Temperature Optimum [°C]
20	Turnover Number [1/s]

KI Value

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KI Value on EC 3.4.22.B62 - cathepsin L3

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Ki VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.00000905

cathepsin K inhibitor II

Fasciola hepatica

-

in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C

718252

0.0003365

Z-Phe-Ala-CHN2

Fasciola hepatica

-

in 100 mM sodium phosphate buffer (pH 6.0) containing 1 mM dithiothreitol and 1 mM EDTA, at 37°C

718252