3.4.22.B62: cathepsin L3

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For detailed information about cathepsin L3, go to the full flat file.

Reaction

70fold preference for tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin over typical cathepsin substrates with hydrophobic or aliphatic residues in the S2 position. Efficiently cleaves type I collagen over different pH and temperature conditions =

Synonyms

cathepsin L clade 3, cathepsin L3, CL3, CL3-1, CL3-2, FhCL3, FheCL3, NEJ protein 8, newly excysted juvenile protein 8, SmCL3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B62 cathepsin L3

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Results	in table
8	AA Sequence
1	Application
8	Cloned(Commentary)
1	Expression
6	General Information
34	Inhibitors
17	kcat/KM [mM/s]
2	Ki Value [mM]
20	KM Value [mM]
5	Localization
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
17	Organism
3	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
2	Protein Variants
5	Purification (Commentary)
1	Reaction
15	Reference
11	Source Tissue
39	Substrates and Products (Substrate)
5	Subunits
26	Synonyms
1	Temperature Optimum [°C]
20	Turnover Number [1/s]

Application

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Application on EC 3.4.22.B62 - cathepsin L3

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APPLICATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

drug development

Fasciola hepatica

Q9GRW6

cathepsin L3 is a protease that plays important roles during the life cycle of fluke. Due to its particular collagenolytic activity it is considered an attractive drug target in the infective phase of Fasciola hepatica

755072