3.4.22.B62: cathepsin L3

This is an abbreviated version!
For detailed information about cathepsin L3, go to the full flat file.

Word Map on EC 3.4.22.B62

3.4.22.B62

cathepsins

fasciola

hepatica

worm

schistosoma

fluke

peptidases

schistosomiasis

mansoni

adjuvant-free

japonicum

samarium

fasciolosis

collagenolytic

drug development

Reaction

70fold preference for tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin over typical cathepsin substrates with hydrophobic or aliphatic residues in the S2 position. Efficiently cleaves type I collagen over different pH and temperature conditions =

Synonyms

cathepsin L clade 3, cathepsin L3, CL3, CL3-1, CL3-2, FhCL3, FheCL3, NEJ protein 8, newly excysted juvenile protein 8, SmCL3

ECTree

3 Hydrolases

3.4 Acting on peptide bonds (peptidases)

3.4.22 Cysteine endopeptidases

3.4.22.B62 cathepsin L3

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Results	in table
8	AA Sequence
1	Application
8	Cloned(Commentary)
1	Expression
6	General Information
34	Inhibitors
17	kcat/KM [mM/s]
2	Ki Value [mM]
20	KM Value [mM]
5	Localization
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
17	Organism
3	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
2	Protein Variants
5	Purification (Commentary)
1	Reaction
15	Reference
11	Source Tissue
39	Substrates and Products (Substrate)
5	Subunits
26	Synonyms
1	Temperature Optimum [°C]
20	Turnover Number [1/s]

Reference

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Reference on EC 3.4.22.B62 - cathepsin L3

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668999

Harmsen, M.M.; Cornelissen, J.B.; Buijs, H.E.; Boersma, W.J.; Jeurissen, S.H.; van Milligen, F.J.

Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide

Int. J. Parasitol.

675-682

2004

Fasciola hepatica (Q9GRW4), Fasciola hepatica (Q9GRW6)

15111089

690690

Tkalcevic, J.; Ashman, K.; Meeusen, E.

Fasciola hepatica: rapid identification of newly excysted juvenile proteins

Biochem. Biophys. Res. Commun.

213

169-174

1995

Fasciola hepatica (P80532)

7639732

691126

Cancela, M.; Acosta, D.; Rinaldi, G.; Silva, E.; Duran, R.; Roche, L.; Zaha, A.; Carmona, C.; Tort, J.F.

A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica

Biochimie

1461-1475

2008

Fasciola hepatica

18573308

694073

Corvo, I.; Cancela, M.; Cappetta, M.; Pi-Denis, N.; Tort, J.F.; Roche, L.

The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen

Mol. Biochem. Parasitol.

167

41-47

2009

Fasciola hepatica

19383516

695238

Reszka, N.; Cornelissen, J.B.; Harmsen, M.M.; Bienkowska-Szewczyk, K.; de Bree, J.; Boersma, W.J.; Rijsewijk, F.A.

Fasciola hepatica procathepsin L3 protein expressed by a baculovirus recombinant can partly protect rats against fasciolosis

Vaccine

2987-2993

2005

Fasciola hepatica (Q9GRW6), Fasciola hepatica

15811644

709951

Robinson, M.W.; Menon, R.; Donnelly, S.M.; Dalton, J.P.; Ranganathan, S.

An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host

Mol. Cell. Proteomics

1891-1907

2009

Fasciola hepatica (B3TM67), Fasciola hepatica (B3TM68)

19443417

718252

Robinson, M.W.; Corvo, I.; Jones, P.M.; George, A.M.; Padula, M.P.; To, J.; Cancela, M.; Rinaldi, G.; Tort, J.F.; Roche, L.; Dalton, J.P.

Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica

PLoS Negl. Trop. Dis.

e1012

2011

Fasciola hepatica

21483711

732474

Zawistowska-Deniziak, A.; Wasyl, K.; Norbury, L.J.; Wesolowska, A.; Bien, J.; Grodzik, M.; Wisniewski, M.; Baska, P.; Wedrychowicz, H.

Characterization and differential expression of cathepsin L3 alleles from Fasciola hepatica

Mol. Biochem. Parasitol.

190

27-37

2013

Fasciola hepatica (B9VXS1), Fasciola hepatica (B9VXS2), Fasciola hepatica

23770026

732674

Corvo, I.; ODonoghue, A.J.; Pastro, L.; Pi-Denis, N.; Eroy-Reveles, A.; Roche, L.; McKerrow, J.H.; Dalton, J.P.; Craik, C.S.; Caffrey, C.R.; Tort, J.F.

Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica

PLoS Negl. Trop. Dis.

e2269

2013

Fasciola hepatica

23875031

753661

Celias, D.P.; Corvo, I.; Silvane, L.; Tort, J.F.; Chiapello, L.S.; Fresno, M.; Arranz, A.; Motran, C.C.; Cervi, L.

Cathepsin L3 from Fasciola hepatica induces NLRP3 inflammasome alternative activation in murine dendritic cells

Front. Immunol.

552

2019

Fasciola hepatica (B3TM67), Fasciola hepatica

30967874

754672

Mebius, M.M.; Op Heij, J.M.J.; Tielens, A.G.M.; de Groot, P.G.; Urbanus, R.T.; van Hellemond, J.J.

Fibrinogen and fibrin are novel substrates for Fasciola hepatica cathepsin L peptidases

Mol. Biochem. Parasitol.

221

10-13

2018

Fasciola hepatica (B3TM67), Fasciola hepatica, Schistosoma mansoni (B4XC67), Schistosoma mansoni

29414671

754803

Ferraro, F.; Merlino, A.; Gil, J.; Cerecetto, H.; Corvo, I.; Cabrera, M.

Cathepsin L inhibitors with activity against the liver fluke identified from a focus library of quinoxaline 1,4-di-N-oxide derivatives

Molecules

2348

2019

Fasciola hepatica (B3TM67)

31247891

755072

Hernandez Alvarez, L.; Naranjo Feliciano, D.; Hernandez Gonzalez, J.E.; de Oliveira Soares, R.O.; Barreto Gomes, D.E.; Pascutti, P.G.

Insights into the Interactions of Fasciola hepatica cathepsin L3 with a substrate and potential novel inhibitors through in silico approaches

PLoS Negl. Trop. Dis.

e0003759

2015

Fasciola hepatica (Q9GRW6), Fasciola hepatica

25978322