3.4.22.B62: cathepsin L3

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For detailed information about cathepsin L3, go to the full flat file.

Reaction

70fold preference for tosyl-Gly-Pro-Arg-7-amido-4-methylcoumarin over typical cathepsin substrates with hydrophobic or aliphatic residues in the S2 position. Efficiently cleaves type I collagen over different pH and temperature conditions =

Synonyms

cathepsin L clade 3, cathepsin L3, CL3, CL3-1, CL3-2, FhCL3, FheCL3, NEJ protein 8, newly excysted juvenile protein 8, SmCL3

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.B62 cathepsin L3

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Results	in table
8	AA Sequence
1	Application
8	Cloned(Commentary)
1	Expression
6	General Information
34	Inhibitors
17	kcat/KM [mM/s]
2	Ki Value [mM]
20	KM Value [mM]
5	Localization
7	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
17	Organism
3	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
1	Posttranslational Modification
2	Protein Variants
5	Purification (Commentary)
1	Reaction
15	Reference
11	Source Tissue
39	Substrates and Products (Substrate)
5	Subunits
26	Synonyms
1	Temperature Optimum [°C]
20	Turnover Number [1/s]

Cloned

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Cloned on EC 3.4.22.B62 - cathepsin L3

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CLONED (Commentary)

ORGANISM

UNIPROT

LITERATURE

-

Fasciola hepatica

-

691126

baculovirus produced procathepsin L3 partly protects rats against fasciolosis, whereas the same coding region expressed in yeast does not

Fasciola hepatica

Q9GRW6

695238

expressed in Escherichia coli BL21 and Pichia pastoris X33 cells

Fasciola hepatica

B9VXS1, B9VXS2

732474

expressed in Hansenula polymorpha

Fasciola hepatica

-

732674

expressed in Hansenula polymorpha strain NCYC 495

Fasciola hepatica

-

694073

expressed in Pichia angusta

Fasciola hepatica

-

718252

recombinant expression of a CL3 cDNA in Saccharomyces cerevisiae results in secretion of the proenzyme form

Fasciola hepatica

Q9GRW4, Q9GRW6

668999

the proenzyme is expressed in the methylotrophic yeast Hansenula polymorpha and the mature enzyme is obtained from the culture medium

Fasciola hepatica

-

694073