3.4.22.57: caspase-4
This is an abbreviated version!
For detailed information about caspase-4, go to the full flat file.
Word Map on EC 3.4.22.57
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3.4.22.57
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inflammasome
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pyroptosis
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chop
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lps
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caspase-5
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non-canonical
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stress-mediated
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gsdmd
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glucose-regulated
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perk
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stress-associated
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pyrin
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gadd153
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aif
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salubrinal
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speck-like
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atf-6
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eif2alpha
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pkr-like
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gasdermin-d
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inflammasome-mediated
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medicine
- 3.4.22.57
- inflammasome
-
pyroptosis
-
chop
- lps
- caspase-5
-
non-canonical
-
stress-mediated
-
gsdmd
-
glucose-regulated
-
perk
-
stress-associated
- pyrin
-
gadd153
- aif
- salubrinal
-
speck-like
- atf-6
- eif2alpha
-
pkr-like
-
gasdermin-d
-
inflammasome-mediated
- medicine
Reaction
strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =
Synonyms
C14.007, Cas4, CASP-4, CASP4, caspase 4, caspase-4, ICE(rel)-II, ICH-2 protease, ICH-3 protease, ICH3 protease, TX, TX protease
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 3.4.22.57 - caspase-4
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proteolytic modification
proteolytic modification
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expression in baculovirus-infected insect cells as 30000 Da proteins lacking the propeptide. Automaturation into p20 and p10 subunits occurs within the cells
proteolytic modification
synthesized as larger proenzyme which is proteolytically processed to form heterodimeric active enzyme
proteolytic modification
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cleavage of pro-caspase-4 when cells are treated with stress-inducing reagents
proteolytic modification
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tunicamycin and thapsigargin induce caspase-4 mRNA expression and protein activation, cleavage of caspase-4 is not affected by overexpression of Bcl-2