Activating Compound | Comment | Organism | Structure |
---|---|---|---|
tunicamycin | activates caspase-4. Activation of caspase-4 preceeds that of caspase-9 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
LEVD-CHO | a caspase-4 inhibitor, suppresses both the apoptosis and caspase-9 activation | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
procaspase-9 + H2O | Homo sapiens | - |
caspase-9 + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | tunicamycin and thapsigargin induce caspase-4 mRNA expression and protein activation, cleavage of caspase-4 is not affected by overexpression of Bcl-2 | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
neuron | - |
Homo sapiens | - |
SH-SY5Y cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
procaspase-9 + H2O | - |
Homo sapiens | caspase-9 + ? | - |
? | |
procaspase-9 + H2O | human recombinant active caspase-4 cleaves wild-type and D330A mutant caspase-9 at residue D315, but not the D315A mutant | Homo sapiens | caspase-9 + ? | - |
? |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | tunicamycin and thapsigargin induce caspase-4 mRNA expression and protein activation | up |
General Information | Comment | Organism |
---|---|---|
evolution | caspase-4 is a member of the caspase-1 family | Homo sapiens |
physiological function | caspase-4 directly activates caspase-9 in endoplasmic reticulum stress-induced apoptosis in SH-SY5Y cells, interaction between caspase-4 and caspase-9 in endoplasmic reticulum stress-induced apoptosis, overview | Homo sapiens |