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3.4.22.57: caspase-4

This is an abbreviated version!
For detailed information about caspase-4, go to the full flat file.

Word Map on EC 3.4.22.57

Reaction

strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =

Synonyms

C14.007, Cas4, CASP-4, CASP4, caspase 4, caspase-4, ICE(rel)-II, ICH-2 protease, ICH-3 protease, ICH3 protease, TX, TX protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.57 caspase-4

Substrates Products

Substrates Products on EC 3.4.22.57 - caspase-4

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SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
Ac-Leu-Glu-Val-Asp-7-amido-4-trifluoro methylcoumarin + H2O
7-amino-4-trifluoromethylcoumarin + Ac-Leu-Glu-Val-Asp
show the reaction diagram
-
10 microM, 2 h, 37°C, reaction stopped with HCl
-
-
?
acetyl-DEVD-4-nitroanilide + H2O
acetyl-DEVD + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-DQMD-4-nitroanilide + H2O
acetyl-DQMD + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-LEVD-4-nitroanilide + H2O
acetyl-LEVD + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-LEVDGW-amide + H2O
?
show the reaction diagram
-
preferred peptide substrate
-
-
?
acetyl-Tyr-Val-Ala-Asp-4-nitroanilide + H2O
acetyl-Tyr-Val-Ala-Asp + 4-nitroaniline
show the reaction diagram
-
-
-
?
acetyl-VEID-4-nitroanilide + H2O
acetyl-VEID + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-VQVD-4-nitroanilide + H2O
acetyl-VQVD + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-WEHD-7-amido-4-methylcoumarin + H2O
acetyl-WEHD + 7-amino-4-methylcoumarin
show the reaction diagram
-
WEHD is the optimal tetrapeptide recognition motif
-
-
?
acetyl-YEVD-4-nitroanilide + H2O
acetyl-YEVD + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-YVAD-4-nitroanilide + H2O
acetyl-YVAD + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
acetyl-YVAD-amido-4-methylcoumarin + H2O
acetyl-YVAD + amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
cowpox serpin CrmA + H2O
?
show the reaction diagram
-
-
-
-
?
LEVD-7-amido-4-trifluoromethylcoumarin + H2O
LEVD + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
p35 + H2O
?
show the reaction diagram
-
-
-
-
?
poly(ADP-ribose)polymerase + H2O
?
show the reaction diagram
-
-
-
-
?
pro-caspase-3 + H2O
p12 + pro-p17
show the reaction diagram
-
-
-
?
procaspase-1 + H2O
caspase-1 + ?
show the reaction diagram
procaspase-9 + H2O
caspase-9 + ?
show the reaction diagram
succinyl-YVAD-4-nitroanilide + H2O
succinyl-YVAD + 4-nitroaniline
show the reaction diagram
succinyl-YVAD-amido-4-methylcoumarin + H2O
succinyl-YVAD + amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
additional information
?
-