3.4.22.57: caspase-4
This is an abbreviated version!
For detailed information about caspase-4, go to the full flat file.
Word Map on EC 3.4.22.57
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3.4.22.57
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inflammasome
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pyroptosis
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chop
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lps
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caspase-5
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non-canonical
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stress-mediated
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gsdmd
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glucose-regulated
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perk
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stress-associated
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pyrin
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gadd153
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aif
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salubrinal
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speck-like
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atf-6
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eif2alpha
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pkr-like
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gasdermin-d
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inflammasome-mediated
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medicine
- 3.4.22.57
- inflammasome
-
pyroptosis
-
chop
- lps
- caspase-5
-
non-canonical
-
stress-mediated
-
gsdmd
-
glucose-regulated
-
perk
-
stress-associated
- pyrin
-
gadd153
- aif
- salubrinal
-
speck-like
- atf-6
- eif2alpha
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pkr-like
-
gasdermin-d
-
inflammasome-mediated
- medicine
Reaction
strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =
Synonyms
C14.007, Cas4, CASP-4, CASP4, caspase 4, caspase-4, ICE(rel)-II, ICH-2 protease, ICH-3 protease, ICH3 protease, TX, TX protease
ECTree
3.4.22.57 caspase-4Advanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.4.22.57 - caspase-4
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
LEVD-7-amido-4-trifluoromethylcoumarin + H2O
LEVD + 7-amino-4-trifluoromethylcoumarin
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?
LEVD-7-amido-4-trifluoromethylcoumarin + H2O
LEVD + 7-amino-4-trifluoromethylcoumarin
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?
procaspase-1 + H2O
caspase-1 + ?
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caspase-4 processes caspase-1 and enhances secretion of IL-1beta in transfected COS-1 cells
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?
additional information
?
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the enzyme is involved in cytokine activation
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?
additional information
?
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the production of the enzyme induces activation of CPP32 like caspase
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?
additional information
?
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overexpression of ICH-2 in insect cell induces apoptosis
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?
additional information
?
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the enzyme is capable of inducing apoptosis in transfected cells such as fibroblasts and may play a role in apoptotic cell death
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?
additional information
?
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overexpression of the enzyme induces apoptosis
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?
additional information
?
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caspase-4 can function as an ER-stress-specific caspase in humans, and may be involved in pathogenesis of Alzheimer's disease
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?
additional information
?
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protective role of CARD only protein in Rip2/caspase-1/caspase-4-mediated HeLa cell death. CARD only protein binds and inhibits caspase-4 activation
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?
additional information
?
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familial Alzheimer's disease-linked presenilin-1 mutation accelerates the cleavage of caspase-4 under the endoplasmic reticulum stress and results in the activation of caspase-9 and caspase-3, apoptosis signal, without releasing cytochrome-c
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?
additional information
?
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misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms
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?
additional information
?
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caspase-4 physically interacts with its central molecule caspase-1
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?
