3.4.22.57: caspase-4
This is an abbreviated version!
For detailed information about caspase-4, go to the full flat file.
Word Map on EC 3.4.22.57
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3.4.22.57
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inflammasome
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pyroptosis
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chop
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lps
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caspase-5
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non-canonical
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stress-mediated
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gsdmd
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glucose-regulated
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perk
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stress-associated
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pyrin
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gadd153
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aif
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salubrinal
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speck-like
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atf-6
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eif2alpha
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pkr-like
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gasdermin-d
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inflammasome-mediated
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medicine
- 3.4.22.57
- inflammasome
-
pyroptosis
-
chop
- lps
- caspase-5
-
non-canonical
-
stress-mediated
-
gsdmd
-
glucose-regulated
-
perk
-
stress-associated
- pyrin
-
gadd153
- aif
- salubrinal
-
speck-like
- atf-6
- eif2alpha
-
pkr-like
-
gasdermin-d
-
inflammasome-mediated
- medicine
Reaction
strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =
Synonyms
C14.007, Cas4, CASP-4, CASP4, caspase 4, caspase-4, ICE(rel)-II, ICH-2 protease, ICH-3 protease, ICH3 protease, TX, TX protease
ECTree
3.4.22.57 caspase-4Advanced search results
results (
results (Cloned
Cloned on EC 3.4.22.57 - caspase-4
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CLONED (Commentary) 
ORGANISM
UNIPROT
LITERATURE
expression in baculovirus-infected insect cells as 30000 Da proteins lacking the propeptide. Automaturation into p20 and p10 subunits occurs within the cells
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expression in Escherichia coli
expression of wild-type, native caspase-4, of C-terminal Myc-tagged wild-type vcaspase-4, and of caspase-4 mutant C285A in COS-1 cells, co-expression with caspase-1
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full-length clones are originally transfected into various host cells, including COS-M6, RAT-1 and HeLa
