Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
35000 | - |
x * 35000, active enzyme, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
SH-EP1 cell | - |
Homo sapiens | - |
Subunits | Comment | Organism |
---|---|---|
? | x * 35000, active enzyme, SDS-PAGE | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Cas4 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | the dominant negative form of IkappaBalpha suppresses the expression of caspase-4 | down |
Homo sapiens | enhancement of nuclear factor-kappaB activity by p65 (RelA) overexpression increases the expression of caspase-4 at both mRNA and protein levels | up |
General Information | Comment | Organism |
---|---|---|
malfunction | when caspase-4 activity is blocked by the dominant negative form of nuclear factor-kappaB, Fas-induced cell death is substantially reduced | Homo sapiens |
physiological function | caspase-4 activity is required for Fas-induced cell apoptosis | Homo sapiens |