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3.4.22.57: caspase-4

This is an abbreviated version!
For detailed information about caspase-4, go to the full flat file.

Word Map on EC 3.4.22.57

Reaction

strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-/- but also cleaves at Asp-Glu-Val-Asp-/- =

Synonyms

C14.007, Cas4, CASP-4, CASP4, caspase 4, caspase-4, ICE(rel)-II, ICH-2 protease, ICH-3 protease, ICH3 protease, TX, TX protease

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.57 caspase-4

Expression

Expression on EC 3.4.22.57 - caspase-4

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EXPRESSION
ORGANISM
UNIPROT
LITERATURE
apoptosis-independent cell death is accompanied by increased expression of the inflammatory marker, caspase-4. Caspase-4 is upregulated in Pt1 cells and induced by interferons
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c-Rel as well as other endoplasmic reticulum stress genes directly modulate expression of caspase-4
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c-Rel is a negative regulator of caspase-4, e.g. in EBV lymphoblastoid cells
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caspase-4 protein expression is strongly induced in the lesional stratum corneum of patients suffering from psoriasis, a common chronic inflammatory disease
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enhancement of nuclear factor-kappaB activity by p65 (RelA) overexpression increases the expression of caspase-4 at both mRNA and protein levels
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mRNA expression of the pro-form of caspase-4 is up-regulated 2fold after poly-I:C stimulation
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the dominant negative form of IkappaBalpha suppresses the expression of caspase-4
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tunicamycin and thapsigargin induce caspase-4 mRNA expression and protein activation
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