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3.4.22.37: gingipain R

This is an abbreviated version!
For detailed information about gingipain R, go to the full flat file.

Word Map on EC 3.4.22.37

Reaction

hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1 =

Synonyms

Arg gingipain, Arg-gingipain, Arg-gingipain A, Arg-gingipain B, Arg-gingipains B, Arg-gingivain-55 proteinase, Arg-gingivain-70 proteinase, Arg-gingivain-75 proteinase, Arg-gingivain-specific proteinase, Arg-ginigipain A, Arg-ginigipain B, Arg-specific cysteine protease, Arg-specific cysteine proteinase, Arg-specific cysteine proteinase gingipain, Arg-specific gingipain, Arg-specific gingipain protease, Arg-X proteinase, Arg-X-specific Arg gingipain, Argingipain, arginine gingipain, arginine-gingipain, Arginine-specific cysteine protease, arginine-specific cysteine proteinase, Arginine-specific gingipain, arginine-specific gingipain 2, arginine-specific gingipain B, arginine-specific gingipain proteinase, Arginine-specific gingivain, arginine-X specific cysteine proteinase, gingipain, gingipain B, gingipain R, gingipain R1, gingipain R2, Gingipain-1, gingipain-R, Gingivain, arginine-specific, high molecular mass arginine-specific gingipain A, high molecular weight gingipain A, high-molecular-mass arginine-specific gingipain, HRgpA, HrgpB, low molecular weight gingipain B, More, mt-RgpA, mt-RgpB, RgB, RGP, Rgp proteinase, RGP-1, RGP-2, RgpA, RgpA proteinase, RgpA(cat), RgpB

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.37 gingipain R

KI Value

KI Value on EC 3.4.22.37 - gingipain R

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0029
2,6-bis-(4-amidinobenzyl)-cyclohexanone
at pH 7.6 and 37°C
0.536
benzamidine
at pH 7.6 and 37°C
0.013 - 0.03
bis-benzamidine with urea linker
0.0015 - 0.0022
E64
-
-
0.00000024
KYT-1
-
at 40°C and pH 7.5
0.1
KYT-36
-
Ki above 0.1 mM, at 40°C and pH 7.5
0.00004
KYT-41
-
at 40°C and pH 7.5
0.005
lactoferrin
-
pH 8.0, 37°C, a kinetic analysis of the inhibition of Arg-specific proteolytic activity of purified gingivalis RgpA/Kgp proteinase-adhesin complexes by lactoferrin demonstrates time-dependent inhibition with a first-order inactivation rate constant (kinact) of 0.023/min
-
0.107
Pentamidine
at pH 7.6 and 37°C
0.00000085 - 0.0000021
prodomain of arginine-specific gingipain A
-
0.0000053 - 0.0000062
prodomain of arginine-specific gingipain B
-
0.0099
RLMAAKAESRK
at pH 7.5 and 37°C
0.0013
RRLMAAKAES
at pH 7.5 and 37°C
0.0013
RRLMAAKAESR
at pH 7.5 and 37°C
0.00096
RRLMAAKAESRK
at pH 7.5 and 37°C
additional information
additional information
-