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Literature summary for 3.4.22.37 extracted from

  • Kataoka, S.; Baba, A.; Suda, Y.; Takii, R.; Hashimoto, M.; Kawakubo, T.; Asao, T.; Kadowaki, T.; Yamamoto, K.
    A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy (2014), FASEB J., 28, 3564-3578.
    View publication on PubMed
Search for more literature for 3.4.22.37

Inhibitors

Inhibitors Comment Organism Structure
KYT-1 i.e. Cbz-Lys-Arg-CO-Lys-N(NH3)2 Porphyromonas gingivalis
KYT-36
-
 Porphyromonas gingivalis
KYT-41
-
 Porphyromonas gingivalis

Organism

Organism UniProt Comment Textmining
Porphyromonas gingivalis
-
-
-
Porphyromonas gingivalis ATCC 33277
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Porphyromonas gingivalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis N-alpha-benzoyl-DL-arginine + 4-nitroaniline
-
 ?
N-alpha-benzoyl-DL-arginine-4-nitroanilide + H2O
-
 Porphyromonas gingivalis ATCC 33277 N-alpha-benzoyl-DL-arginine + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
Arg-gingipain
-
 Porphyromonas gingivalis
Arginine-specific gingipain
-
 Porphyromonas gingivalis
RGP
-
 Porphyromonas gingivalis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000024
-
 KYT-1 at 40°C and pH 7.5 Porphyromonas gingivalis
0.00004
-
 KYT-41 at 40°C and pH 7.5 Porphyromonas gingivalis
0.1
-
 KYT-36 Ki above 0.1 mM, at 40°C and pH 7.5 Porphyromonas gingivalis