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3.4.22.37: gingipain R

This is an abbreviated version!
For detailed information about gingipain R, go to the full flat file.

Word Map on EC 3.4.22.37

Reaction

hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1 =

Synonyms

Arg gingipain, Arg-gingipain, Arg-gingipain A, Arg-gingipain B, Arg-gingipains B, Arg-gingivain-55 proteinase, Arg-gingivain-70 proteinase, Arg-gingivain-75 proteinase, Arg-gingivain-specific proteinase, Arg-ginigipain A, Arg-ginigipain B, Arg-specific cysteine protease, Arg-specific cysteine proteinase, Arg-specific cysteine proteinase gingipain, Arg-specific gingipain, Arg-specific gingipain protease, Arg-X proteinase, Arg-X-specific Arg gingipain, Argingipain, arginine gingipain, arginine-gingipain, Arginine-specific cysteine protease, arginine-specific cysteine proteinase, Arginine-specific gingipain, arginine-specific gingipain 2, arginine-specific gingipain B, arginine-specific gingipain proteinase, Arginine-specific gingivain, arginine-X specific cysteine proteinase, gingipain, gingipain B, gingipain R, gingipain R1, gingipain R2, Gingipain-1, gingipain-R, Gingivain, arginine-specific, high molecular mass arginine-specific gingipain A, high molecular weight gingipain A, high-molecular-mass arginine-specific gingipain, HRgpA, HrgpB, low molecular weight gingipain B, More, mt-RgpA, mt-RgpB, RgB, RGP, Rgp proteinase, RGP-1, RGP-2, RgpA, RgpA proteinase, RgpA(cat), RgpB

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.37 gingipain R

Molecular Weight

Molecular Weight on EC 3.4.22.37 - gingipain R

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MOLECULAR WEIGHT
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
43000
-
x * 43000, both enzyme forms, SDS-PAGE
44000
-
Porphyromonas gingivalis, gel filtration
45000
48000
48120 - 48150
48200
-
x * 48200, MALDI TOF mass spectrometry
50000
55000
-
Porphyromonas gingivalis, enzyme form Arg-gingivain-55
56000
-
x * 56000, RgpB, calculated from the deduced amino acid sequence
70000
-
Porphyromonas gingivalis, enzyme form Arg-gingivain-70
75000
-
Porphyromonas gingivalis, enzyme form Arg-gingivain-75
95000
98000
x * 98000, isoform HRgpA, SDS-PAGE
additional information
-
the enzyme exists as multiple MW species. The major forms are: 110000 MW, 95000 MW, 70000-90000 MW, and 50000 MW. The first two being a complex of the 50000 MW catalytic subunit with hemagglutinins, with or without an added membrane anchorage peptide. The other forms are single-chain enzymes. The 95000 MW and the 50000 MW form are found predominantly in culture medium, the 110000 and 70000-90000 MW foms are associated with membranous fractions of the bacteria