3.4.22.37: gingipain R

This is an abbreviated version!
For detailed information about gingipain R, go to the full flat file.

Reaction

hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1 =

Synonyms

Arg gingipain, Arg-gingipain, Arg-gingipain A, Arg-gingipain B, Arg-gingipains B, Arg-gingivain-55 proteinase, Arg-gingivain-70 proteinase, Arg-gingivain-75 proteinase, Arg-gingivain-specific proteinase, Arg-ginigipain A, Arg-ginigipain B, Arg-specific cysteine protease, Arg-specific cysteine proteinase, Arg-specific cysteine proteinase gingipain, Arg-specific gingipain, Arg-specific gingipain protease, Arg-X proteinase, Arg-X-specific Arg gingipain, Argingipain, arginine gingipain, arginine-gingipain, Arginine-specific cysteine protease, arginine-specific cysteine proteinase, Arginine-specific gingipain, arginine-specific gingipain 2, arginine-specific gingipain B, arginine-specific gingipain proteinase, Arginine-specific gingivain, arginine-X specific cysteine proteinase, gingipain, gingipain B, gingipain R, gingipain R1, gingipain R2, Gingipain-1, gingipain-R, Gingivain, arginine-specific, high molecular mass arginine-specific gingipain A, high molecular weight gingipain A, high-molecular-mass arginine-specific gingipain, HRgpA, HrgpB, low molecular weight gingipain B, More, mt-RgpA, mt-RgpB, RgB, RGP, Rgp proteinase, RGP-1, RGP-2, RgpA, RgpA proteinase, RgpA(cat), RgpB

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.22 Cysteine endopeptidases

                3.4.22.37 gingipain R

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Results	in table
28	Activating Compound
125	AA Sequence
9	Application
1	CAS Registry Number
11	Cloned(Commentary)
3	Crystallization (Commentary)
32	General Information
10	General Stability
6	IC50 Value
113	Inhibitors
22	Ki Value [mM]
4	KM Value [mM]
28	Localization
7	Metals/Ions
22	Molecular Weight [Da]
100	Natural Substrates/ Products (Substrates)
312	Organism
11	PDB ID
26	pH Optimum
4	pH Range
1	pH Stability
10	pI Value
9	Posttranslational Modification
12	Protein Variants
23	Purification (Commentary)
8	Reaction
15	Reaction Type
113	Reference
1	Renatured (Commentary)
1	Source Tissue
8	Specific Activity [micromol/min/mg]
3	Storage Stability
225	Substrates and Products (Substrate)
39	Subunits
279	Synonyms
25	Temperature Optimum [°C]
1	Temperature Range [°C]
1	Temperature Stability [°C]
2	Turnover Number [1/s]

IC50 Value

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IC50 Value on EC 3.4.22.37 - gingipain R

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IC50 VALUE [mM]

INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

0.0000071 - 0.0000237

prodomain of arginine-specific gingipain B

3 entries

-

0.248

RLMAAKAESRK

Porphyromonas gingivalis

B2RKK0

at pH 7.5 and 37°C

731489

0.242

RRLMAAKAESR

Porphyromonas gingivalis

B2RKK0

at pH 7.5 and 37°C

731489

0.145

RRLMAAKAESRK

Porphyromonas gingivalis

B2RKK0

at pH 7.5 and 37°C

731489

0.0000071

prodomain of arginine-specific gingipain B

Porphyromonas gingivalis

-

isoform RgpB, with azocoll as substrate, in 200 mM Tris-HCl, 5 mM CaCl2, 150 mM NaCl, and 0.02% (w/v) NaN3, pH 7.6, supplemented with 10 mM L-cysteine, at 37°C

731334

-

0.0000072

prodomain of arginine-specific gingipain B

Porphyromonas gingivalis

-

isoform RgpB, with H-Arg-7-amido-4-methylcoumarin as substrate, in 200 mM Tris-HCl, 5 mM CaCl2, 150 mM NaCl, and 0.02% (w/v) NaN3, pH 7.6, supplemented with 10 mM L-cysteine, at 37°C

731334

-

0.0000237

prodomain of arginine-specific gingipain B

Porphyromonas gingivalis

-

isoform RgpB, with Nalpha-benzoyl-L-arginine 4-nitroanilide as substrate, in 200 mM Tris-HCl, 5 mM CaCl2, 150 mM NaCl, and 0.02% (w/v) NaN3, pH 7.6, supplemented with 10 mM L-cysteine, at 37°C

731334

-