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3.4.22.37: gingipain R

This is an abbreviated version!
For detailed information about gingipain R, go to the full flat file.

Word Map on EC 3.4.22.37

Reaction

hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1 =

Synonyms

Arg gingipain, Arg-gingipain, Arg-gingipain A, Arg-gingipain B, Arg-gingipains B, Arg-gingivain-55 proteinase, Arg-gingivain-70 proteinase, Arg-gingivain-75 proteinase, Arg-gingivain-specific proteinase, Arg-ginigipain A, Arg-ginigipain B, Arg-specific cysteine protease, Arg-specific cysteine proteinase, Arg-specific cysteine proteinase gingipain, Arg-specific gingipain, Arg-specific gingipain protease, Arg-X proteinase, Arg-X-specific Arg gingipain, Argingipain, arginine gingipain, arginine-gingipain, Arginine-specific cysteine protease, arginine-specific cysteine proteinase, Arginine-specific gingipain, arginine-specific gingipain 2, arginine-specific gingipain B, arginine-specific gingipain proteinase, Arginine-specific gingivain, arginine-X specific cysteine proteinase, gingipain, gingipain B, gingipain R, gingipain R1, gingipain R2, Gingipain-1, gingipain-R, Gingivain, arginine-specific, high molecular mass arginine-specific gingipain A, high molecular weight gingipain A, high-molecular-mass arginine-specific gingipain, HRgpA, HrgpB, low molecular weight gingipain B, More, mt-RgpA, mt-RgpB, RgB, RGP, Rgp proteinase, RGP-1, RGP-2, RgpA, RgpA proteinase, RgpA(cat), RgpB

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.37 gingipain R

General Stability

General Stability on EC 3.4.22.37 - gingipain R

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GENERAL STABILITY
ORGANISM
UNIPROT
LITERATURE
1% SDS slightly decreases enzyme activity
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Ca2+ stabilizes
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Ca2+ stabilizes all forms of gingipain R
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Ca2+ stabilizes the enzyme, while glycyl-glycine destabilizes the enzyme
Ca2+ stabilizes the isozymes, while glycyl-glycine destabilizes the isozymes
enzyme is completely inactivated in 8 M urea
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expression of RgpB is required for correct glycosylation and stability of monomeric RgpA from strain W50
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Irreversible loss of activity during lyophilization
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RgpB is stable and active in buffers containing 6 M urea, 0.1% SDS, 1% Triton X-100, and 1% octyl or decylpyranoside
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RgpB is stable to denaturing agents, e.g. urea, SDS, Triton X-100, and 1% octyl or decylpyranoside
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