3.4.22.37: gingipain R
This is an abbreviated version!
For detailed information about gingipain R, go to the full flat file.
Word Map on EC 3.4.22.37
-
3.4.22.37
-
porphyromonas
-
gingivalis
-
periodontal
-
proteinases
-
adhesins
-
lysine-specific
-
hemagglutinins
-
hemagglutination
-
protease-activated
-
keystone
-
periodontopathogenic
-
fimbriae
-
crevicular
-
diagnostics
-
actinomycetemcomitans
-
biotechnology
-
molecular biology
-
forsythia
-
johnsoniae
-
periodontopathic
-
gingivalis-induced
-
black-pigmented
-
par-2
-
subgingival
-
peptidylarginine
-
tooth-supporting
-
tannerella
-
gliding
-
autoaggregation
-
medicine
-
pharmacology
-
drug development
-
lys-specific
- 3.4.22.37
- porphyromonas
- gingivalis
- periodontal
- proteinases
- adhesins
-
lysine-specific
- hemagglutinins
-
hemagglutination
-
protease-activated
-
keystone
-
periodontopathogenic
-
fimbriae
-
crevicular
- diagnostics
- actinomycetemcomitans
- biotechnology
- molecular biology
- forsythia
- johnsoniae
-
periodontopathic
-
gingivalis-induced
-
black-pigmented
- par-2
-
subgingival
-
peptidylarginine
-
tooth-supporting
-
tannerella
-
gliding
-
autoaggregation
- medicine
- pharmacology
- drug development
-
lys-specific
Reaction
hydrolysis of proteins and small molecule substrates, with a preference for Arg in P1 =
Synonyms
Arg gingipain, Arg-gingipain, Arg-gingipain A, Arg-gingipain B, Arg-gingipains B, Arg-gingivain-55 proteinase, Arg-gingivain-70 proteinase, Arg-gingivain-75 proteinase, Arg-gingivain-specific proteinase, Arg-ginigipain A, Arg-ginigipain B, Arg-specific cysteine protease, Arg-specific cysteine proteinase, Arg-specific cysteine proteinase gingipain, Arg-specific gingipain, Arg-specific gingipain protease, Arg-X proteinase, Arg-X-specific Arg gingipain, Argingipain, arginine gingipain, arginine-gingipain, Arginine-specific cysteine protease, arginine-specific cysteine proteinase, Arginine-specific gingipain, arginine-specific gingipain 2, arginine-specific gingipain B, arginine-specific gingipain proteinase, Arginine-specific gingivain, arginine-X specific cysteine proteinase, gingipain, gingipain B, gingipain R, gingipain R1, gingipain R2, Gingipain-1, gingipain-R, Gingivain, arginine-specific, high molecular mass arginine-specific gingipain A, high molecular weight gingipain A, high-molecular-mass arginine-specific gingipain, HRgpA, HrgpB, low molecular weight gingipain B, More, mt-RgpA, mt-RgpB, RgB, RGP, Rgp proteinase, RGP-1, RGP-2, RgpA, RgpA proteinase, RgpA(cat), RgpB
ECTree
3.4.22.37 gingipain RAdvanced search results
results (
results (Engineering
Engineering on EC 3.4.22.37 - gingipain R
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
PROTEIN VARIANTS 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
DELTA435-507
-
largely inactive, incorrect localization in culture supernatant and periplasm
additional information
additional information
-
4 naturally occuring enzyme deficient mutants: rgpA-deficient mutant shows 77% activity compared to the wild-type activity with type I collagen, while a rgpB-deficent mutant shows 82% activity, and a double-deficient mutant strain shows only 6% activity, another mutant lacking the to arginine-specific isozyme and the lysine-specific gingipain KGP shows 5% remaining activity
additional information
-
mutant RgpA-deficient isogenic strain W501 and RgpB-deficient isogenic strain D7 show 50% of wild-type strain W50 enzyme activity
additional information
-
Rgp null mutant strain KDP133 shows platelet aggregation similar to the wild-type strain ATCC 33277, while neither the Rgp/Kgp null mutant strain, nor the adhesin null mutant strain show platelet aggregation
additional information
-
strain W501 is deficient for RgpA, strain E8 for Rgp, and strain D7 for RgpB
additional information
-
construction of a strain producing Kgp proteinase without the adhesin domains in a Rgp/Kgp/adhesin-null mutant, mutant strains 33277, KDP133, and KDP137 phenotypes, overview
additional information
-
construction of enzyme-deficient mutants KDP136 with DELTArgpADELTArgpBDELTAkgp, and KDP133 with DELTAkgp. The mutants do not, in contrast to the wild-type enzyme, inhibit cellular proliferation and don not arrest the cell cycle in the G0/G1 phase as well as decrease the expression levels of the cell-cycle regulatory molecules cyclin D and cyclin E in murine ST2 cells, overview
additional information
-
gingipain-deficient Porphyromonas gingivalis mutants lacking both Arg- and Lys-gingipains are unable to induce interleukin-1beta, interleukin-6, and interleukin-8 degradation
additional information
-
construction of enzyme-deficient mutants KDP136 with DELTArgpADELTArgpBDELTAkgp, and KDP133 with DELTAkgp. The mutants do not, in contrast to the wild-type enzyme, inhibit cellular proliferation and don not arrest the cell cycle in the G0/G1 phase as well as decrease the expression levels of the cell-cycle regulatory molecules cyclin D and cyclin E in murine ST2 cells, overview
-
additional information
-
4 naturally occuring enzyme deficient mutants: rgpA-deficient mutant shows 77% activity compared to the wild-type activity with type I collagen, while a rgpB-deficent mutant shows 82% activity, and a double-deficient mutant strain shows only 6% activity, another mutant lacking the to arginine-specific isozyme and the lysine-specific gingipain KGP shows 5% remaining activity
-
additional information
-
construction of a strain producing Kgp proteinase without the adhesin domains in a Rgp/Kgp/adhesin-null mutant, mutant strains 33277, KDP133, and KDP137 phenotypes, overview
-
