3.4.22.32: Stem bromelain
This is an abbreviated version!
For detailed information about Stem bromelain, go to the full flat file.
Word Map on EC 3.4.22.32
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3.4.22.32
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papain
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ficin
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comosus
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chymotrypsin
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ananas
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hydrolysates
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allergen
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proteinases
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ige
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debridement
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neuraminidase
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alcalase
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cystatins
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virion
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hymenoptera
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flavourzyme
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medicine
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kininogens
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prick
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eschar
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tender
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haemagglutinins
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food industry
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actinidin
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ha2
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agriculture
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chymopapain
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mucolytic
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pharmacology
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pancreatin
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ige-binding
- 3.4.22.32
- papain
- ficin
- comosus
- chymotrypsin
- ananas
- hydrolysates
- allergen
- proteinases
- ige
-
debridement
- neuraminidase
- alcalase
- cystatins
- virion
- hymenoptera
- flavourzyme
- medicine
- kininogens
-
prick
-
eschar
-
tender
-
haemagglutinins
- food industry
- actinidin
- ha2
- agriculture
- chymopapain
-
mucolytic
- pharmacology
- pancreatin
-
ige-binding
Reaction
broad specificity for cleavage of proteins, but strong preference for Z-Arg-Arg-/-NHMec amongst small molecule substrates =
Synonyms
acidic bromelain stem proteinase, ACMD2_17643, BRM, Bromelain, Bromelain, stem, EC 3.4.22.4, EC 3.4.4.24, Pineapple stem bromelain, SBA, Sbm, stem bromelain
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Natural Substrates Products on EC 3.4.22.32 - Stem bromelain
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
CD25 + H2O
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bromelain proteolytically cleaved cell-surface CD25 from activated CD4+ T cells, a mechanism of action to exert therapeutic benefits in inflammatory conditions, overview
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additional information
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enzyme reduces the amount of prostaglandin-E2 and substance P in vivo in inflammatory process in rats, while in vitro it induces an increase in the concentration of these inflammation mediators, thus the enzyme does not directly interact with the compounds, but has an antiinflammatory effect in vivo
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additional information
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bromelain from pineapple stem shows therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease, mechanism, overview. Bromelain primary long-term effect is abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation. These changes in adhesion are correlated with rapid re-expression of the bromelain-sensitive CD62L/L-selectin molecules that mediate rolling following in vivo bromelain treatment and minimal re-expression of CD128
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additional information
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bromelain possesses anti-inflammatory activity and reduces blood viscosity, prevents the aggregation of blood platelets, and improves ischemia-reperfusion injury, I/R, in a skeletal muscle model in adult Sprague-Dawley rats. The enzyme increases phosphorylation of Akt in rat heart both in the cytosolic and the nuclear fraction following I/R
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additional information
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CD4+ T cells retain the ability to divide after bromelain treatment
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additional information
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effects of orally administered bromelain in an ovalbumin-induced murine model of acute allergic airway disease in female C57BL/6J mice, bromelain causes decreased methacholine sensitivity, reduction in bronchoalveolar lavage eosinophils and interleukin-13 concentrations, as well as of CD19+ B cells and CD8+ T cells, as compared with controls, overview. Bromelain modulates lung lymphocytes during acute asthma
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additional information
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phosphorylation and consequent degradation of IkappaBalpha, the inhibitor of the nuclear importing sequences of NF-kappaB, is blocked by bromelain, which also shows anti-inflammatory, anti-invasive and anti-metastatic properties, anti-tumor-initiating effects of bromelain in 2-stage mouse skin tumorigenesis model, overview. Bromelain treatment resulted in upregulation of p53 and Bax and subsequent activation of caspase 3 and caspase 9 with concomitant decrease in Bcl-2, and bromelain inhibits DMBA-induced DNA alkylation damage, overview
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