3.4.22.32: Stem bromelain
This is an abbreviated version!
For detailed information about Stem bromelain, go to the full flat file.
Word Map on EC 3.4.22.32
-
3.4.22.32
-
papain
-
ficin
-
comosus
-
chymotrypsin
-
ananas
-
hydrolysates
-
allergen
-
proteinases
-
ige
-
debridement
-
neuraminidase
-
alcalase
-
cystatins
-
virion
-
hymenoptera
-
flavourzyme
-
medicine
-
kininogens
-
prick
-
eschar
-
tender
-
haemagglutinins
-
food industry
-
actinidin
-
ha2
-
agriculture
-
chymopapain
-
mucolytic
-
pharmacology
-
pancreatin
-
ige-binding
- 3.4.22.32
- papain
- ficin
- comosus
- chymotrypsin
- ananas
- hydrolysates
- allergen
- proteinases
- ige
-
debridement
- neuraminidase
- alcalase
- cystatins
- virion
- hymenoptera
- flavourzyme
- medicine
- kininogens
-
prick
-
eschar
-
tender
-
haemagglutinins
- food industry
- actinidin
- ha2
- agriculture
- chymopapain
-
mucolytic
- pharmacology
- pancreatin
-
ige-binding
Reaction
broad specificity for cleavage of proteins, but strong preference for Z-Arg-Arg-/-NHMec amongst small molecule substrates =
Synonyms
acidic bromelain stem proteinase, ACMD2_17643, BRM, Bromelain, Bromelain, stem, EC 3.4.22.4, EC 3.4.4.24, Pineapple stem bromelain, SBA, Sbm, stem bromelain
ECTree
Advanced search results
Application
Application on EC 3.4.22.32 - Stem bromelain
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
agriculture
-
a concentration of 0.0003 mM of bromelain is sufficient for 90% growth inhibition of Fusarium verticillioides. Bromelain also inhibits the growth of Fusarium oxysporum f. sp. melonis and Fuarium proliferatum. The enzyme shows a potential use as an effective agent for crop protection
food industry
medicine
pharmacology
-
stem bromelain immobilized on chitosan beads without glutaraldehyde yields a food-safe biocatalyst for unstable real wine future application
food industry
-
the immobilized stem bromelain has productive biotechnological applications in wine-making
-
oral bromelain may potentially modify inflammation within the gastrointestinal tract via local proteolytic activity within the colonic microenvironment
medicine
-
the complex between stem bromelain and polyclonal Fab* monomer can serve as a model with potential in vivo and industrial application especially in homogenous reaction phases and development of subunit vaccines owing to preponderance of hydrophobic interaction and better diffusion potential of Fab' than of intact IgG
medicine
-
bromelain shows antitumorigenic potential by inducing apoptosis-related proteins along with inhibition of nuclear factor-kappa B driven cyclooxygenase-2 expression by blocking the mitogen-activated protein kinase and Akt/protein kinase B signaling in 7,12-dimethylbenz(a)anthracene-12-O-tetradecanoylphorbol-13-acetate-induced mouse skin tumors
medicine
-
stem bromelain triggers an Akt-dependent survival pathway in the heart, revealing a mechanism of cardioprotective action and a potential therapeutic target against ischemia/perfusion injury
medicine
-
bromelain from pineapple stem shows therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease, mechanism, overview. Bromelain primary long-term effect is abrogation of firm adhesion of leukocytes to blood vessels at the site of inflammation. These changes in adhesion are correlated with rapid re-expression of the bromelain-sensitive CD62L/L-selectin molecules that mediate rolling following in vivo bromelain treatment and minimal re-expression of CD128
medicine
-
bromelain possesses anti-inflammatory activity and reduces blood viscosity, prevents the aggregation of blood platelets, and improves ischemia-reperfusion injury, I/R, in a skeletal muscle model in adult Sprague-Dawley rats. The enzyme increases phosphorylation of Akt in rat heart both in the cytosolic and the nuclear fraction following I/R
medicine
-
effects of orally administered bromelain in an ovalbumin-induced murine model of acute allergic airway disease in female C57BL/6J mice, bromelain causes decreased methacholine sensitivity, reduction in bronchoalveolar lavage eosinophils and interleukin-13 concentrations, as well as of CD19+ B cells and CD8+ T cells, as compared with controls, overview. Bromelain modulates lung lymphocytes during acute asthma
medicine
-
bromelain has anti-cancer activity, as well as antithrombotic, fibrinolytic, antiedematous, and burn debridement properties
medicine
-
the nonnative form of SBM shows only a fraction of the native protein's enzymatic activity but is more effective at inhibiting cell growth and displays better antitumorigenic properties than native SBM
medicine
-
bromelain relieves osteoarthritis. Bromelain is used as an adjuvant therapeutic approach in the treatment of chronic inflammatory, malignant, and autoimmune diseases. Bromelain prevents or minimizes the severity of angina pectoris and transient ischemic attack. Bromelain influences blood coagulation by increasing the serum fibrinolytic ability and by inhibiting the synthesis of fibrin. Bromelain counteracts some of the effects of certain intestinal pathogens like Vibrio cholera and Escherichia coli, whose enterotoxin causes diarrhea. The anticancerous activity of bromelain is due to its direct impact on cancer cells and their microenvironment, as well as on the modulation of immune, inflammatory, and haemostatic systems. Bromelain is used for treating acute inflammation and sports injuries. Bromelain applied as a cream (35% bromelain in a lipid base) can be beneficial for debridement of necrotic tissue and acceleration of healing
medicine
bromelain exhibits various fibrinolytic, anti-edematous, anti-thrombotic, and anti-inflammatory activities supporting its application for many therapeutic benefits. Effects of bromelain on the pro-wound healing activities and the regenerative properties of mesenchymal stem cells. The combined use of bromelain and dexamethasone sodium phosphate stimulated the pro-wound healing activities and the regenerative properties of mesenchymal stem cells better than bromelain and dexamethasone alone
medicine
bromelain has gained wide acceptance and compliance as a phytotherapeutical drug. Cysteine proteases in pineapple (Ananas comosus) plants are phytotherapeutical agents that demonstrate anti-edematous, anti-inflammatory, anti-thrombotic and fibrinolytic activities
medicine
potential of the stem bromelain to be developed as an active compound for lung cancer therapy because of its high anti-proliferation and apoptosis-induction activity in A549 cells
bromelain is pharmacologically active against B16F10 melanoma cells with complete inhibition of tumor cell proliferation in vitro
pharmacology
in vitro anti-cancer activity (anti-proliferation and apoptosis induction) comparison of the freeze-dried and spray-dried bromelain from pineapple stems
pharmacology
Ananas comosus AGB 772
-
bromelain is pharmacologically active against B16F10 melanoma cells with complete inhibition of tumor cell proliferation in vitro
-