3.4.21.B6: prostasin
This is an abbreviated version!
For detailed information about prostasin, go to the full flat file.
Word Map on EC 3.4.21.B6
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3.4.21.B6
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matriptase
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aldosterone
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hai-1
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furin
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gpi-anchored
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aprotinin
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amiloride-sensitive
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glycosylphosphatidylinositol-anchored
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hepsin
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nexin-1
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kunitz-type
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camostat
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medicine
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profilaggrin
-
enac-mediated
- 3.4.21.B6
- matriptase
- aldosterone
- hai-1
- furin
-
gpi-anchored
- aprotinin
-
amiloride-sensitive
-
glycosylphosphatidylinositol-anchored
- hepsin
- nexin-1
-
kunitz-type
- camostat
- medicine
- profilaggrin
-
enac-mediated
Reaction
endoprotease activity. Trypsin-like enzymatic activity =
Synonyms
CAP-1, CAP1, CAP1/PRSS8, channel activating protease 1, channel activating protease-1, channel-activating protease 1, channel-activating protease-1, LD47230p, prostasin, prostasin/PRSS8, PRSS8, S01.159, tracheal-prostasin
ECTree
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Posttranslational Modification
Posttranslational Modification on EC 3.4.21.B6 - prostasin
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proteolytic modification
the zymogen in vitro is activated by notopleural
proteolytic modification
matriptase is an effective activator of the prostasin zymogen through direct proteolytic cleavage at its zymogen activation site. Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway
proteolytic modification
the prostasin zymogen is incapable of auto-activation and requires proteolytic processing by matriptase for conversion into an active protease
proteolytic modification
prostasin zymogen is incapable of auto-activation and requires proteolytic processing by a second protease, i.e. matriptase, for conversion into an active protease