3.4.21.B6: prostasin

This is an abbreviated version!
For detailed information about prostasin, go to the full flat file.

Reaction

endoprotease activity. Trypsin-like enzymatic activity =

Synonyms

CAP-1, CAP1, CAP1/PRSS8, channel activating protease 1, channel activating protease-1, channel-activating protease 1, channel-activating protease-1, LD47230p, prostasin, prostasin/PRSS8, PRSS8, S01.159, tracheal-prostasin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B6 prostasin

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Results	in table
17	Activating Compound
5	AA Sequence
13	Application
1	CAS Registry Number
21	Cloned(Commentary)
3	Crystallization (Commentary)
686	Disease/ Diagnostics
7	Expression
28	General Information
69	Inhibitors
36	Ki Value [mM]
18	KM Value [mM]
14	Localization
18	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
57	Organism
3	pH Optimum
1	pH Range
1	pI Value
6	Posttranslational Modification
10	Protein Variants
13	Purification (Commentary)
1	Reaction
6	Reaction Type
57	Reference
148	Source Tissue
44	Substrates and Products (Substrate)
5	Subunits
31	Synonyms
17	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 3.4.21.B6 - prostasin

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

proform epithelial sodium channel + H2O

mature epithelial sodium channel + ?

Homo sapiens

Q16651

-

732088

-

-

?

proform filaggrin + H2O

mature filaggrin + ?

Mus musculus

Q9ESD1

-

731623

-

-

?

proform G protein-coupled protease activated receptor-2 + H2O

mature G protein-coupled protease activated receptor-2 + ?

Homo sapiens

Q16651

-

732088

-

-

?

Protein + H2O

?

3 entries

Toll-like receptor 4 + H2O

truncated Toll-like receptor 4 + ectodomain

2 entries

additional information

?

-

3 entries

Protein + H2O

?

Homo sapiens

-

-

651845

-

651845

?

Protein + H2O

?

Homo sapiens

-

-

652134

-

652134

?

Protein + H2O

?

Mus musculus

-

-

651463

-

651463

?

Toll-like receptor 4 + H2O

truncated Toll-like receptor 4 + ectodomain

Homo sapiens

Q16651

reduction in the full-length form and reduction of the activation of the substrate

732562

-

-

?

Toll-like receptor 4 + H2O

truncated Toll-like receptor 4 + ectodomain

Mus musculus

Q9ESD1

reduction in the full-length form and reduction of the activation of the substrate

732562

-

-

?

additional information

?

-

Homo sapiens

Q16651

critical role in the regulation of extracellular sodium ion transport via its activation of the epithelial cell sodium channel

695021

-

-

?

additional information

?

-

Homo sapiens

-

critical role in the regulation of extracellular sodium ion transport via its activation of the epithelial cell sodium channel

695021

-

-

?

additional information

?

-

Homo sapiens

Q16651

activated prostasin appears to target several downstream effector proteins, including the epithelial sodium channel and the G protein-coupled protease activated receptor-2, which are both matriptase substrates

732088

-

-

?