3.4.21.B6: prostasin

This is an abbreviated version!
For detailed information about prostasin, go to the full flat file.

Reaction

endoprotease activity. Trypsin-like enzymatic activity =

Synonyms

CAP-1, CAP1, CAP1/PRSS8, channel activating protease 1, channel activating protease-1, channel-activating protease 1, channel-activating protease-1, LD47230p, prostasin, prostasin/PRSS8, PRSS8, S01.159, tracheal-prostasin

ECTree

     3 Hydrolases

         3.4 Acting on peptide bonds (peptidases)

             3.4.21 Serine endopeptidases

                3.4.21.B6 prostasin

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Results	in table
17	Activating Compound
5	AA Sequence
13	Application
1	CAS Registry Number
21	Cloned(Commentary)
3	Crystallization (Commentary)
686	Disease/ Diagnostics
7	Expression
28	General Information
69	Inhibitors
36	Ki Value [mM]
18	KM Value [mM]
14	Localization
18	Molecular Weight [Da]
10	Natural Substrates/ Products (Substrates)
57	Organism
3	pH Optimum
1	pH Range
1	pI Value
6	Posttranslational Modification
10	Protein Variants
13	Purification (Commentary)
1	Reaction
6	Reaction Type
57	Reference
148	Source Tissue
44	Substrates and Products (Substrate)
5	Subunits
31	Synonyms
17	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 3.4.21.B6 - prostasin

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

7-amido-4-carbamoylmethylcoumarin-KHYRSVAS-K(DNP)R + H2O

?

Homo sapiens

-

-

671687

-

-

?

7-amido-4-carbamoylmethylcoumarin-KHYRSVAW-K(DNP)R + H2O

?

Homo sapiens

-

-

671687

-

-

?

acetyl-DHYR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-DHYR + 7-amino-4-carbamoylmethylcoumarin

Homo sapiens

-

suboptimal substrate

671687

-

-

?

acetyl-KDYR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-KDYR + 7-amino-4-carbamoylmethylcoumarin

Homo sapiens

-

suboptimal substrate

671687

-

-

?

acetyl-KHDR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-KHDR + 7-amino-4-carbamoylmethylcoumarin

Homo sapiens

-

suboptimal substrate

671687

-

-

?

acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-KHYR + 7-amino-4-carbamoylmethylcoumarin

2 entries

acetyl-KHYR-7-amido-4-methylcoumarin + H2O

acetyl-KHYR + 7-amino-4-methylcoumarin

2 entries

acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-PRLR + 7-amino-4-carbamoylmethylcoumarin

2 entries

benzyloxycarbonyl-Gly-Pro-Arg-7-amido-4-trifluoromethylcoumarin

benzyloxycarbonyl-Gly-Pro-Arg + 7-amino-4-trifluoromethylcoumarin

Homo sapiens

-

-

651845

-

651845

?

D-Phe-Phe-Arg 4-methylcoumarin 7-amide

?

Homo sapiens

-

-

651845

-

651845

?

D-Phe-Phe-Arg-7-amido-4-methylcoumarin + H2O

D-Phe-Phe-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

651845, 673905

-

-

?

D-Pro-Phe-Arg 4-methylcoumarin 7-amide

?

Homo sapiens

-

-

651845

-

651845

?

D-Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O

?

Homo sapiens

-

fluorogenic substrate

652134

-

652134

?

D-Pro-Phe-Arg-7-amido-4-methylcoumarin + H2O

D-Pro-Phe-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

651845, 673905

-

-

?

D-Val-Leu-Arg 4-methylcoumarin 7-amide

?

Homo sapiens

-

-

651845

-

651845

?

D-Val-Leu-Arg-7-amido-4-methylcoumarin + H2O

D-Val-Leu-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

651845, 673905

-

-

?

dumpy + H2O

?

Drosophila melanogaster

Q9W2C8

i.e. a zona pellucida-domain protein

755064

-

-

?

epithelial sodium channel gamma subunit + H2O

?

Mus musculus

-

the enzyme activates epithelial sodium channels by inducing cleavage of the gamma-subunit at a site distal to the furin cleavage site

680878

-

-

?

human Toll-like receptor 4 + H2O

truncated Toll-like receptor 4 + ectodomain

Homo sapiens

Q16651

reduction in the full-length form and reduction of the activation of the substrate. Substrate mutations K560A/K561A, K595A and R598A in the ectodomain abolish or reduce the enzyme activity, respectively

732562

-

-

?

N-t-Boc-Gln-Ala-Arg-7-amido-4-methylcoumarin + H2O

?

Homo sapiens

Q16651

-

676929

-

-

?

proform epithelial sodium channel + H2O

mature epithelial sodium channel + ?

Homo sapiens

Q16651

-

732088

-

-

?

proform filaggrin + H2O

mature filaggrin + ?

Mus musculus

Q9ESD1

-

731623

-

-

?

proform G protein-coupled protease activated receptor-2 + H2O

mature G protein-coupled protease activated receptor-2 + ?

Homo sapiens

Q16651

-

732088

-

-

?

Protein + H2O

?

3 entries

Toll-like receptor 4 + H2O

truncated Toll-like receptor 4 + ectodomain

2 entries

tosyl-Gly-L-Pro-L-Arg-4-nitroanilide + H2O

?

Homo sapiens

-

-

671251

-

-

?

Z-Gly-Pro-Arg-7-amido-4-methylcoumarin + H2O

Z-Gly-Pro-Arg + 7-amino-4-methylcoumarin

Homo sapiens

-

-

651845, 673905

-

-

?

additional information

?

-

8 entries

acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-KHYR + 7-amino-4-carbamoylmethylcoumarin

Homo sapiens

-

-

671687

-

-

?

acetyl-KHYR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-KHYR + 7-amino-4-carbamoylmethylcoumarin

Homo sapiens

-

optimal substrate

671687

-

-

?

acetyl-KHYR-7-amido-4-methylcoumarin + H2O

acetyl-KHYR + 7-amino-4-methylcoumarin

Homo sapiens

-

-

671687

-

-

?

acetyl-KHYR-7-amido-4-methylcoumarin + H2O

acetyl-KHYR + 7-amino-4-methylcoumarin

Homo sapiens

Q16651

-

693192

-

-

?

acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-PRLR + 7-amino-4-carbamoylmethylcoumarin

Homo sapiens

-

-

707872

-

-

?

acetyl-PRLR-7-amido-4-carbamoylmethylcoumarin + H2O

acetyl-PRLR + 7-amino-4-carbamoylmethylcoumarin

Homo sapiens

-

suboptimal substrate

671687

-

-

?

Protein + H2O

?

Homo sapiens

-

-

651845

-

651845

?

Protein + H2O

?

Homo sapiens

-

-

652134

-

652134

?

Protein + H2O

?

Mus musculus

-

-

651463

-

651463

?

Toll-like receptor 4 + H2O

truncated Toll-like receptor 4 + ectodomain

Homo sapiens

Q16651

reduction in the full-length form and reduction of the activation of the substrate

732562

-

-

?

Toll-like receptor 4 + H2O

truncated Toll-like receptor 4 + ectodomain

Mus musculus

Q9ESD1

reduction in the full-length form and reduction of the activation of the substrate

732562

-

-

?

additional information

?

-

Homo sapiens

-

7-amido-4-carbamoylmethylcoumarin-KHYRIVAS-K(DNP)R completely inactive

671687

-

-

?

additional information

?

-

Homo sapiens

Q16651

critical role in the regulation of extracellular sodium ion transport via its activation of the epithelial cell sodium channel

695021

-

-

?

additional information

?

-

Homo sapiens

-

critical role in the regulation of extracellular sodium ion transport via its activation of the epithelial cell sodium channel

695021

-

-

?

additional information

?

-

Homo sapiens

-

active prostasin does not cleave the epidermal growth factor receptor extracellular domain directly, purified active prostasin also does not cleave purified epidermal growth factor receptor

709925

-

-

?

additional information

?

-

Homo sapiens

Q16651

activated prostasin appears to target several downstream effector proteins, including the epithelial sodium channel and the G protein-coupled protease activated receptor-2, which are both matriptase substrates

732088

-

-

?

additional information

?

-

Homo sapiens

Q16651

Lys or Arg residues are amino acids targeted by the enzyme

732562

-

-

?

additional information

?

-

Homo sapiens

Q16651

the matriptase zymogen is no substrate of prostasin

732088

-

-

?

additional information

?

-

Mus musculus

Q9ESD1

Lys or Arg residues are amino acids targeted by the enzyme

732562

-

-

?